RT Journal Article
SR Electronic
T1 Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0027-21.2021
DO 10.1523/ENEURO.0027-21.2021
VO 8
IS 3
A1 Karla C. M. Costa
A1 Tamires A. V. Brigante
A1 Gabriel G. Fernandes
A1 Davi S. Scomparin
A1 Franciele F. Scarante
A1 Danielle P. de Oliveira
A1 Alline C. Campos
YR 2021
UL http://www.eneuro.org/content/8/3/ENEURO.0027-21.2021.abstract
AB The Coronavirus disease-2019 (COVID-19) presents a variability of clinical symptoms, ranging from asymptomatic to severe respiratory and systemic conditions. In a cohort of patients, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), beyond the classical respiratory manifestations, induces anosmia. Evidence has suggested SARS-CoV-2-induced anosmia can be the result of neurodegeneration of the olfactory pathway. Neurologic symptoms associated with COVID-19 have been reported; however, the precise mechanism and possible long-lasting effects remain poorly investigated. Preclinical models are valuable tools for describing and testing new possible treatments for neurologic disorders. In this way, the zebrafish (Danio rerio) organism model represents an attractive tool in the field of neuroscience, showing economic and logistic advantages besides genetic and physiologic similarities with mammalian, including the brain structure and functions. Besides, its external embryonic development, high availability of eggs, and fast development allows easy genetic manipulation and fast replications. In the present review, we suggest that the zebrafish model can be advantageous to investigate the neurologic features of COVID-19.