RT Journal Article
SR Electronic
T1 Large-Scale and Multiscale Networks in the Rodent Brain during Novelty Exploration
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0494-20.2021
DO 10.1523/ENEURO.0494-20.2021
VO 8
IS 3
A1 Michael X Cohen
A1 Bernhard Englitz
A1 Arthur S. C. França
YR 2021
UL http://www.eneuro.org/content/8/3/ENEURO.0494-20.2021.abstract
AB Neural activity is coordinated across multiple spatial and temporal scales, and these patterns of coordination are implicated in both healthy and impaired cognitive operations. However, empirical cross-scale investigations are relatively infrequent, because of limited data availability and to the difficulty of analyzing rich multivariate datasets. Here, we applied frequency-resolved multivariate source-separation analyses to characterize a large-scale dataset comprising spiking and local field potential (LFP) activity recorded simultaneously in three brain regions (prefrontal cortex, parietal cortex, hippocampus) in freely-moving mice. We identified a constellation of multidimensional, inter-regional networks across a range of frequencies (2–200 Hz). These networks were reproducible within animals across different recording sessions, but varied across different animals, suggesting individual variability in network architecture. The theta band (∼4–10 Hz) networks had several prominent features, including roughly equal contribution from all regions and strong inter-network synchronization. Overall, these findings demonstrate a multidimensional landscape of large-scale functional activations of cortical networks operating across multiple spatial, spectral, and temporal scales during open-field exploration.