RT Journal Article
SR Electronic
T1 Developing of Focal Ischemia in the Hippocampus or the Amygdala Reveals a Regional Compensation Rule for Fear Memory Acquisition
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0398-20.2021
DO 10.1523/ENEURO.0398-20.2021
VO 8
IS 2
A1 Yu, Cheng-Long
A1 Li, Jin-Nan
A1 Gan, Ping
A1 Wang, Li-Ping
A1 Yang, Yue-Xiong
A1 Yu, Da-Fu
A1 Mao, Rong-Rong
A1 Xu, Fu-Qiang
A1 Zhou, Qi-Xin
A1 Richter-Levin, Gal
A1 Xu, Lin
A1 Zhou, Heng
YR 2021
UL http://www.eneuro.org/content/8/2/ENEURO.0398-20.2021.abstract
AB Circuit compensation is often observed in patients with acute ischemic stroke, suggesting the importance of the interaction between brain regions. Also, contextual fear memory is an association between multisensory contexts and fearful stimuli, for which the interaction between the hippocampus and the amygdala is believed to be critical. To understand how focal ischemia in one region could influence the other region, we used a modified photo-thrombosis to induce focal ischemia in the hippocampus or the amygdala or both in freely-moving rats. We found that the learning curve and short-term memory (STM) were not affected in the rats although focal ischemia was induced 5 h before learning in either the hippocampus or the amygdala; these were impaired by the induction of ischemia in both the regions. Furthermore, the learning curve and STM were impaired when ischemia was induced 24 h before learning in either the hippocampus or the amygdala when the synaptic transmission was altered in one region because of ischemia in the other region. These results suggest that the circuit compensation between the hippocampus and the amygdala is critical for fear memory acquisition.