RT Journal Article SR Electronic T1 Neuronal Network Excitability in Alzheimer’s Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau JF eneuro JO eNeuro FD Society for Neuroscience SP ENEURO.0418-20.2020 DO 10.1523/ENEURO.0418-20.2020 VO 8 IS 2 A1 Syed Faraz Kazim A1 Joon Ho Seo A1 Riccardo Bianchi A1 Chloe S. Larson A1 Abhijeet Sharma A1 Robert K. S. Wong A1 Kirill Y. Gorbachev A1 Ana C. Pereira YR 2021 UL http://www.eneuro.org/content/8/2/ENEURO.0418-20.2020.abstract AB Alzheimer’s disease (AD) is the most frequent neurodegenerative disorder that commonly causes dementia in the elderly. Recent evidence indicates that network abnormalities, including hypersynchrony, altered oscillatory rhythmic activity, interneuron dysfunction, and synaptic depression, may be key mediators of cognitive decline in AD. In this review, we discuss characteristics of neuronal network excitability in AD, and the role of Aβ and tau in the induction of network hyperexcitability. Many patients harboring genetic mutations that lead to increased Aβ production suffer from seizures and epilepsy before the development of plaques. Similarly, pathologic accumulation of hyperphosphorylated tau has been associated with hyperexcitability in the hippocampus. We present common and divergent roles of tau and Aβ on neuronal hyperexcitability in AD, and hypotheses that could serve as a template for future experiments.