PT  - JOURNAL ARTICLE
AU  - Ashwin G. Ramayya
AU  - Andrew I. Yang
AU  - Vivek P. Buch
AU  - John F. Burke
AU  - Andrew G. Richardson
AU  - Cameron Brandon
AU  - Joel M. Stein
AU  - Kathryn A. Davis
AU  - H. Isaac Chen
AU  - Alexander Proekt
AU  - Max B. Kelz
AU  - Brian Litt
AU  - Joshua I. Gold
AU  - Timothy H. Lucas
TI  - Theta Synchrony Is Increased near Neural Populations That Are Active When Initiating Instructed Movement
AID  - 10.1523/ENEURO.0252-20.2020
DP  - 2021 Jan 01
TA  - eneuro
PG  - ENEURO.0252-20.2020
VI  - 8
IP  - 1
4099  - http://www.eneuro.org/content/8/1/ENEURO.0252-20.2020.short
4100  - http://www.eneuro.org/content/8/1/ENEURO.0252-20.2020.full
SO  - eNeuro2021 Jan 01; 8
AB  - Theta oscillations (3–8 Hz) in the human brain have been linked to perception, cognitive control, and spatial memory, but their relation to the motor system is less clear. We tested the hypothesis that theta oscillations coordinate distributed behaviorally relevant neural representations during movement using intracranial electroencephalography (iEEG) recordings from nine patients (n = 490 electrodes) as they performed a simple instructed movement task. Using high frequency activity (HFA; 70–200 Hz) as a marker of local spiking activity, we identified electrodes that were positioned near neural populations that showed increased activity during instruction and movement. We found that theta synchrony was widespread throughout the brain but was increased near regions that showed movement-related increases in neural activity. These results support the view that theta oscillations represent a general property of brain activity that may also play a specific role in coordinating widespread neural activity when initiating voluntary movement.