PT  - JOURNAL ARTICLE
AU  - A. Contestabile
AU  - R. Colangiulo
AU  - M. Lucchini
AU  - E.M. Rouiller
AU  - E. Schmidlin
TI  - Variable Interhemispheric Asymmetry in Layer V of the Supplementary Motor Area following Cervical Hemisection in Adult Macaque Monkeys
AID  - 10.1523/ENEURO.0280-20.2020
DP  - 2020 Sep 01
TA  - eneuro
PG  - ENEURO.0280-20.2020
VI  - 7
IP  - 5
4099  - http://www.eneuro.org/content/7/5/ENEURO.0280-20.2020.short
4100  - http://www.eneuro.org/content/7/5/ENEURO.0280-20.2020.full
SO  - eNeuro2020 Sep 01; 7
AB  - Motor cortical areas from both hemispheres play a role during functional recovery after a unilateral spinal cord injury (SCI). However, little is known about the morphologic and phenotypical differences that a SCI could trigger in corticospinal (CS) neurons of the ipsilesional and contralesional hemisphere. Using an SMI-32 antibody which specifically labeled pyramidal neurons in cortical Layers V, we investigated the impact of a unilateral cervical cord lesion on the rostral part (F6) and caudal part (F3) of the supplementary motor area (SMA) in both hemispheres of eight adult macaque monkeys compared with four intact control monkeys. We observed in F3 (but not in F6) interindividual variable and adaptive interhemispheric asymmetries of SMI-32-positive Layer V neuronal density and dendritic arborization, which are strongly correlated with the extent of the SCI as well as the duration of functional recovery, but not with the extent (percentage) of functional recovery.