PT - JOURNAL ARTICLE AU - Becker, Robert AU - Hervais-Adelman, Alexis TI - Resolving the Connectome, Spectrally-Specific Functional Connectivity Networks and Their Distinct Contributions to Behavior AID - 10.1523/ENEURO.0101-20.2020 DP - 2020 Sep 01 TA - eneuro PG - ENEURO.0101-20.2020 VI - 7 IP - 5 4099 - http://www.eneuro.org/content/7/5/ENEURO.0101-20.2020.short 4100 - http://www.eneuro.org/content/7/5/ENEURO.0101-20.2020.full SO - eNeuro2020 Sep 01; 7 AB - The resting human brain exhibits spontaneous patterns of activity that reflect features of the underlying neural substrate. Examination of interareal coupling of resting-state oscillatory activity has revealed that the brain’s resting activity is composed of functional networks, whose topographies differ depending on oscillatory frequency, suggesting a role for carrier frequency as a means of creating multiplexed, or functionally segregated, communication channels between brain areas. Using canonical correlation analysis (CCA), we examined spectrally resolved resting-state connectivity patterns derived from magnetoencephalography (MEG) recordings to determine the relationship between connectivity intrinsic to different frequency channels and a battery of over a hundred behavioral and demographic indicators, in a group of 89 young healthy participants. We demonstrate that each of the classical frequency bands in the range 1–40 Hz (δ, θ, α, β, and γ) delineates a subnetwork that is behaviorally relevant, spatially distinct, and whose expression is either negatively or positively predictive of individual traits, with the strongest link in the α-band being negative and networks oscillating at different frequencies, such as θ, β, and γ carrying positive function.