PT - JOURNAL ARTICLE AU - Diahann A. M. Atacho AU - Hallur Reynisson AU - Anna Thora Petursdottir AU - Thor Eysteinsson AU - Eirikur Steingrimsson AU - Petur Henry Petersen TI - Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity AID - 10.1523/ENEURO.0412-19.2020 DP - 2020 Mar 01 TA - eneuro PG - ENEURO.0412-19.2020 VI - 7 IP - 2 4099 - http://www.eneuro.org/content/7/2/ENEURO.0412-19.2020.short 4100 - http://www.eneuro.org/content/7/2/ENEURO.0412-19.2020.full SO - eNeuro2020 Mar 01; 7 AB - Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits. We show that the microphthalmia-associated transcription factor (Mitf) plays a central role in intrinsic plasticity of olfactory bulb (OB) projection neurons. Mitral and tufted (M/T) neurons from Mitf mutant mice are hyperexcitable, have a reduced A-type potassium current (IA) and exhibit reduced expression of Kcnd3, which encodes a potassium voltage-gated channel subunit (Kv4.3) important for generating the IA. Furthermore, expression of the Mitf and Kcnd3 genes is activity dependent in OB projection neurons and the MITF protein activates expression from Kcnd3 regulatory elements. Moreover, Mitf mutant mice have changes in olfactory habituation and have increased habituation for an odorant following long-term exposure, indicating that regulation of Kcnd3 is pivotal for long-term olfactory adaptation. Our findings show that Mitf acts as a direct regulator of intrinsic homeostatic feedback and links neuronal activity, transcriptional changes and neuronal function.