RT Journal Article
SR Electronic
T1 More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0337-19.2020
DO 10.1523/ENEURO.0337-19.2020
VO 7
IS 2
A1 Simon Maksour
A1 Lezanne Ooi
A1 Mirella Dottori
YR 2020
UL http://www.eneuro.org/content/7/2/ENEURO.0337-19.2020.abstract
AB The molecular mechanisms governing normal neurodevelopment are tightly regulated by the action of transcription factors. Repressor element 1 (RE1) silencing transcription factor (REST) is widely documented as a regulator of neurogenesis that acts by recruiting corepressor proteins and repressing neuronal gene expression in non-neuronal cells. The REST corepressor 1 (CoREST1), CoREST2, and CoREST3 are best described for their role as part of the REST complex. However, recent evidence has shown the proteins have the ability to repress expression of distinct target genes in a REST-independent manner. These findings indicate that each CoREST paralogue may have distinct and critical roles in regulating neurodevelopment and are more than simply “REST corepressors,” whereby they act as independent repressors orchestrating biological processes during neurodevelopment.