TY - JOUR T1 - Cerebral Contribution to the Execution, But Not Recalibration, of Motor Commands in a Novel Walking Environment JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0493-19.2020 VL - 7 IS - 1 SP - ENEURO.0493-19.2020 AU - Digna de Kam AU - Pablo A. Iturralde AU - Gelsy Torres-Oviedo Y1 - 2020/01/01 UR - http://www.eneuro.org/content/7/1/ENEURO.0493-19.2020.abstract N2 - Human movements are flexible as they continuously adapt to changes in the environment. The recalibration of corrective responses to sustained perturbations (e.g., constant force) altering one’s movement contributes to this flexibility. We asked whether the recalibration of corrective actions involve cerebral structures using stroke as a disease model. We characterized changes in muscle activity in stroke survivors and control subjects before, during, and after walking on a split-belt treadmill moving the legs at different speeds. The recalibration of corrective muscle activity was comparable between stroke survivors and control subjects, which was unexpected given the known deficits in feedback responses poststroke. Also, the intact recalibration in stroke survivors contrasted their limited ability to adjust their muscle activity during steady-state split-belt walking. Our results suggest that the recalibration and execution of motor commands are partially dissociable: cerebral lesions interfere with the execution, but not the recalibration, of motor commands on novel movement demands. ER -