@article {MaksourENEURO.0337-19.2020, author = {Simon Maksour and Lezanne Ooi and Mirella Dottori}, title = {More than a corepressor: the role of CoREST proteins in neurodevelopment}, elocation-id = {ENEURO.0337-19.2020}, year = {2020}, doi = {10.1523/ENEURO.0337-19.2020}, publisher = {Society for Neuroscience}, abstract = {The molecular mechanisms governing normal neurodevelopment are tightly regulated by the action of transcription factors. Repressor element 1 silencing transcription factor (REST) is widely documented as a regulator of neurogenesis that acts by recruiting corepressor proteins and repressing neuronal gene expression in non-neuronal cells. The REST corepressor 1 (CoREST1), CoREST2 and CoREST3 are best described for their role as part of the REST complex. However, recent evidence has shown the proteins have the ability to repress expression of distinct target genes in a REST-independent manner. These findings indicate that each CoREST paralogue may have distinct and critical roles in regulating neurodevelopment and are more than simply {\textquotedblleft}REST corepressors{\textquotedblright}, whereby they act as independent repressors orchestrating biological processes during neurodevelopment.Significance statement The molecular mechanisms governing normal development of the brain are yet to be fully elucidated. The regulation of gene expression by transcription factors plays a significant role in the specification and maturation of neurons and glia. Repressor element 1 silencing transcription factor (REST) has been well characterised as a transcriptional regulator of neurogenesis through the formation of a complex with the REST corepressor (CoREST) proteins. Recently, the CoREST protein family has been shown to independently target unique genes, have distinct expression patterns, and important REST-independent functions during neurodevelopment. Understanding the molecular mechanisms governed by the CoREST family will provide insight into the regulatory networks directing normal neurodevelopment.}, URL = {https://www.eneuro.org/content/early/2020/02/14/ENEURO.0337-19.2020}, eprint = {https://www.eneuro.org/content/early/2020/02/14/ENEURO.0337-19.2020.full.pdf}, journal = {eNeuro} }