RT Journal Article
SR Electronic
T1 A Computational Model of Dual Competition between the Basal Ganglia and the Cortex
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0339-17.2018
DO 10.1523/ENEURO.0339-17.2018
VO 5
IS 6
A1 Meropi Topalidou
A1 Daisuke Kase
A1 Thomas Boraud
A1 Nicolas P. Rougier
YR 2018
UL http://www.eneuro.org/content/5/6/ENEURO.0339-17.2018.abstract
AB We propose a model that includes interactions between the cortex, the basal ganglia (BG), and the thalamus based on a dual competition. We hypothesize that the striatum, the subthalamic nucleus (STN), the internal globus pallidus (GPi), the thalamus, and the cortex are involved in closed feedback loops through the hyperdirect and direct pathways. These loops support a competition process that results in the ability of BG to make a cognitive decision followed by a motor one. Considering lateral cortical interactions, another competition takes place inside the cortex allowing the latter to make a cognitive and a motor decision. We show how this dual competition endows the model with two regimes. One is driven by reinforcement learning and the other by Hebbian learning. The final decision is made according to a combination of these two mechanisms with a gradual transfer from the former to the latter. We confirmed these theoretical results on primates (Macaca mulatta) using a novel paradigm predicted by the model.