PT - JOURNAL ARTICLE AU - Fukuma, Ryohei AU - Yanagisawa, Takufumi AU - Tanaka, Masataka AU - Yoshida, Fumiaki AU - Hosomi, Koichi AU - Oshino, Satoru AU - Tani, Naoki AU - Kishima, Haruhiko TI - Real-Time Neurofeedback to Modulate β-Band Power in the Subthalamic Nucleus in Parkinson’s Disease Patients AID - 10.1523/ENEURO.0246-18.2018 DP - 2018 Nov 01 TA - eneuro PG - ENEURO.0246-18.2018 VI - 5 IP - 6 4099 - http://www.eneuro.org/content/5/6/ENEURO.0246-18.2018.short 4100 - http://www.eneuro.org/content/5/6/ENEURO.0246-18.2018.full SO - eNeuro2018 Nov 01; 5 AB - The β-band oscillation in the subthalamic nucleus (STN) is a therapeutic target for Parkinson’s disease. Previous studies demonstrated that l-DOPA decreases the β-band (13–30 Hz) oscillations with improvement of motor symptoms. However, it has not been elucidated whether patients with Parkinson’s disease are able to control the β-band oscillation voluntarily. Here, we hypothesized that neurofeedback training to control the β-band power in the STN induces plastic changes in the STN of individuals with Parkinson’s disease. We recorded the signals from STN deep-brain stimulation electrodes during operations to replace implantable pulse generators in eight human patients (3 male) with bilateral electrodes. Four patients were induced to decrease the β-band power during the feedback training (down-training condition), whereas the other patients were induced to increase (up-training condition). All patients were blinded to their assigned condition. Adjacent contacts that showed the highest β-band power were selected for the feedback. During the 10 min training, patients were shown a circle whose diameter was controlled by the β-band power of the selected contacts. Powers in the β-band during 5 min resting sessions recorded before and after the feedback were compared. In the down-training condition, the β-band power of the selected contacts decreased significantly after feedback in all four patients (p < 0.05). In contrast, the β-band power significantly increased after feedback in two of four patients in the up-training condition. Overall, the patients could voluntarily control the β-band power in STN in the instructed direction (p < 0.05) through neurofeedback.