RT Journal Article
SR Electronic
T1 Interaction of Cortical and Amygdalar Synaptic Input Modulates the Window of Opportunity for Information Processing in the Rhinal Cortices
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0020-19.2019
DO 10.1523/ENEURO.0020-19.2019
VO 6
IS 4
A1 Janske G. P. Willems
A1 Wytse J. Wadman
A1 Natalie L. M. Cappaert
YR 2019
UL http://www.eneuro.org/content/6/4/ENEURO.0020-19.2019.abstract
AB The perirhinal (PER) and lateral entorhinal (LEC) cortex function as a gateway for information transmission between (sub)cortical areas and the hippocampus. It is hypothesized that the amygdala, a key structure in emotion processing, can modulate PER-LEC neuronal activity before information enters the hippocampal memory pathway. This study determined the integration of synaptic activity evoked by simultaneous neocortical and amygdala electrical stimulation in PER-LEC deep layer principal neurons and parvalbumin (PV) interneurons in mouse brain slices. The data revealed that both deep layer PER-LEC principal neurons and PV interneurons receive synaptic input from the neocortical agranular insular cortex (AiP) and the lateral amygdala (LA). Furthermore, simultaneous stimulation of the AiP and LA never reached the firing threshold in principal neurons of the PER-LEC deep layers. PV interneurons however, mainly showed linear summation of simultaneous AiP and LA inputs and reached their firing threshold earlier. This early PV firing was reflected in the forward shift of the evoked inhibitory conductance in principal neurons, thereby creating a more precise temporal window for coincidence detection, which likely plays a crucial role in information processing.