RT Journal Article
SR Electronic
T1 Background EEG Connectivity Captures the Time-Course of Epileptogenesis in a Mouse Model of Epilepsy
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0059-19.2019
DO 10.1523/ENEURO.0059-19.2019
VO 6
IS 4
A1 Słowiński, Piotr
A1 Sheybani, Laurent
A1 Michel, Christoph M.
A1 Richardson, Mark P.
A1 Quairiaux, Charles
A1 Terry, John R.
A1 Goodfellow, Marc
YR 2019
UL http://www.eneuro.org/content/6/4/ENEURO.0059-19.2019.abstract
AB Large-scale brain networks are increasingly recognized as important for the generation of seizures in epilepsy. However, how a network evolves from a healthy state through the process of epileptogenesis remains unclear. To address this question, here, we study longitudinal epicranial background EEG recordings (30 electrodes, EEG free from epileptiform activity) of a mouse model of mesial temporal lobe epilepsy. We analyze functional connectivity networks and observe that over the time course of epileptogenesis the networks become increasingly asymmetric. Furthermore, computational modelling reveals that a set of nodes, located outside of the region of initial insult, emerges as particularly important for the network dynamics. These findings are consistent with experimental observations, thus demonstrating that ictogenic mechanisms can be revealed on the EEG, that computational models can be used to monitor unfolding epileptogenesis and that both the primary focus and epileptic network play a role in epileptogenesis.