PT  - JOURNAL ARTICLE
AU  - Piotr Słowiński
AU  - Laurent Sheybani
AU  - Christoph M. Michel
AU  - Mark P. Richardson
AU  - Charles Quairiaux
AU  - John R. Terry
AU  - Marc Goodfellow
TI  - Background EEG Connectivity Captures the Time-Course of Epileptogenesis in a Mouse Model of Epilepsy
AID  - 10.1523/ENEURO.0059-19.2019
DP  - 2019 Jul 01
TA  - eneuro
PG  - ENEURO.0059-19.2019
VI  - 6
IP  - 4
4099  - http://www.eneuro.org/content/6/4/ENEURO.0059-19.2019.short
4100  - http://www.eneuro.org/content/6/4/ENEURO.0059-19.2019.full
SO  - eNeuro2019 Jul 01; 6
AB  - Large-scale brain networks are increasingly recognized as important for the generation of seizures in epilepsy. However, how a network evolves from a healthy state through the process of epileptogenesis remains unclear. To address this question, here, we study longitudinal epicranial background EEG recordings (30 electrodes, EEG free from epileptiform activity) of a mouse model of mesial temporal lobe epilepsy. We analyze functional connectivity networks and observe that over the time course of epileptogenesis the networks become increasingly asymmetric. Furthermore, computational modelling reveals that a set of nodes, located outside of the region of initial insult, emerges as particularly important for the network dynamics. These findings are consistent with experimental observations, thus demonstrating that ictogenic mechanisms can be revealed on the EEG, that computational models can be used to monitor unfolding epileptogenesis and that both the primary focus and epileptic network play a role in epileptogenesis.