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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Sub-second analysis of locomotor activity in Parkinsonian mice

Daniil Berezhnoi, Hiba Douja Chehade, Gabriel Simms, Liqiang Chen, Kishore Kumar S. Narasimhan, Shashank M. Dravid and Hong-Yuan Chu
eNeuro 28 July 2025, ENEURO.0014-25.2025; https://doi.org/10.1523/ENEURO.0014-25.2025
Daniil Berezhnoi
1Department of Pharmacology and Physiology, Georgetown University of Medical Center, Washington DC, 20007, United States
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, 20852, United States
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Hiba Douja Chehade
1Department of Pharmacology and Physiology, Georgetown University of Medical Center, Washington DC, 20007, United States
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, 20852, United States
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Gabriel Simms
3Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, United States
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Liqiang Chen
1Department of Pharmacology and Physiology, Georgetown University of Medical Center, Washington DC, 20007, United States
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, 20852, United States
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Kishore Kumar S. Narasimhan
4Department of Psychiatry and Behavioral Sciences, Texas A&M Health Sciences Center, College of Medicine, Texas A&M University, College Station, TX 77845, United States
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Shashank M. Dravid
4Department of Psychiatry and Behavioral Sciences, Texas A&M Health Sciences Center, College of Medicine, Texas A&M University, College Station, TX 77845, United States
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Hong-Yuan Chu
1Department of Pharmacology and Physiology, Georgetown University of Medical Center, Washington DC, 20007, United States
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, 20852, United States
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  • For correspondence: hc948{at}georgetown.edu
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0014-25.2025
PubMed 
40721310
Published By 
Society for Neuroscience
History 
  • Received January 9, 2025
  • Revision received June 21, 2025
  • Accepted June 26, 2025
  • Published online July 28, 2025.
Copyright & Usage 
Copyright © 2025 Berezhnoi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Daniil Berezhnoi1,2,
  2. Hiba Douja Chehade1,2,
  3. Gabriel Simms3,
  4. Liqiang Chen1,2,
  5. Kishore Kumar S. Narasimhan4,
  6. Shashank M. Dravid4 and
  7. Hong-Yuan Chu1,2,*
  1. 1Department of Pharmacology and Physiology, Georgetown University of Medical Center, Washington DC, 20007, United States
  2. 2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, 20852, United States
  3. 3Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, United States
  4. 4Department of Psychiatry and Behavioral Sciences, Texas A&M Health Sciences Center, College of Medicine, Texas A&M University, College Station, TX 77845, United States
  1. ↵*Correspondence should be addressed to Hong-Yuan Chu at hc948{at}georgetown.edu

Author contributions

  1. Author contributions: Conceptualization (DB, HYC); Investigation (DB, GS, HDC, LC, KKN); Formal analysis (DB, KKN, HYC); Validation (DB, LC, KKN, HYC); Writing – original draft (DB, HYC); Writing – Review & Editing (SMD, HYC); Supervision, Project administration and Funding acquisition (SMD, HYC).

Disclosures

  • Behavior recordings were conducted at the Van Andel Research Institute. Data analysis and manuscript preparation were performed and completed at Georgetown University Medical Center. This work was partially supported by research grants from the National Institutes of Health (R01NS121371, R21NS135545, H.Y.C; and R01NS133338, S.M.D. and H.Y.C.), Department of Defense Congressionally Directed Medical Research Programs (W81XWH-21-1-0943, H.Y.C.), and Parkinson’s Foundation (PF-IMP-1045313, H.Y.C.). This work was also funded in whole or in part by Aligning Science Across Parkinson’s (ASAP-020572) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). For the purpose of open access, the authors have applied a CC BY public copyright license to all Author Accepted Manuscripts arising from this submission.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS121371; R21NS135545; R01NS133338
  • DOD | MHS | Congressionally Directed Medical Research Programs (CDMRP)

    W81XWH-21-1-0943
  • Parkinson's Foundation (PF)

    PF-IMP-1045313
  • Aligning Science Across Parkinson's (ASAP)

    ASAP-020572

Online Impact

 

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Article usage: July 2025 to March 2026

AbstractFullPdf
Jul 2025224061
Aug 2025837297306
Sep 2025224190102
Oct 20258514683
Nov 202510211764
Dec 20257813672
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Sub-second analysis of locomotor activity in Parkinsonian mice
Daniil Berezhnoi, Hiba Douja Chehade, Gabriel Simms, Liqiang Chen, Kishore Kumar S. Narasimhan, Shashank M. Dravid, Hong-Yuan Chu
eNeuro 28 July 2025, ENEURO.0014-25.2025; DOI: 10.1523/ENEURO.0014-25.2025

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Sub-second analysis of locomotor activity in Parkinsonian mice
Daniil Berezhnoi, Hiba Douja Chehade, Gabriel Simms, Liqiang Chen, Kishore Kumar S. Narasimhan, Shashank M. Dravid, Hong-Yuan Chu
eNeuro 28 July 2025, ENEURO.0014-25.2025; DOI: 10.1523/ENEURO.0014-25.2025
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