Perirhinal and postrhinal damage have different consequences on attention as assessed in the five-choice serial reaction time task

Abstract

The perirhinal (PER) and postrhinal (POR) cortices, structures in the medial temporal lobe, are implicated in learning and memory. The PER is understood to process object information and the POR to process spatial or contextual information. Whether the medial temporal lobe is dedicated to memory, however, is under debate. In this study, we addressed the hypothesis that the PER and POR are also involved in non-mnemonic cognitive functions. Rats with PER or POR damage and SHAM surgical controls were shaped, trained, and tested on the five-choice serial reaction time (5CSRT) task, which assesses attention and executive function. Rats with PER damage were impaired in acquiring the task and at asymptote, even though processing information about objects was not relevant to the task. When confronted with attentional challenges, rats with PER damage showed a pattern consistent with decreased attentional capacity, increased response errors, and increased impulsive behavior. Rats with POR damage showed intact acquisition and normal asymptotic performance. They also exhibited faster latencies in the absence of speed accuracy trade-off suggesting enhanced response readiness. We suggest this increased response readiness results from decreased automatic monitoring of the local environment, which might normally compete with response readiness. Our findings are consistent with a role for PER in controlled attention and a role for POR in stimulus-driven attention providing evidence that the PER and POR cortices have functions that go beyond memory for objects and memory for scenes and contexts. These findings provide new evidence for functional specialization in the medial temporal lobe.

Significance

The perirhinal (PER) and postrhinal (POR) cortices, structures in the medial temporal lobe, are implicated in learning and memory. Whether medial temporal lobe structures are exclusively dedicated to memory, however, is under debate. We provide evidence for a role for PER in controlled attention and a role for POR in stimulus-driven attention. These findings provide new evidence for functional specialization in the medial temporal lobe.