Flexible and accurate substrate processing with distinct presenilin/γ-secretases in human cortical neurons

Hirotaka Watanabe; Kent Imaizumi; Tetsuo Cai; Zhi Zhou; Taisuke Tomita; Hideyuki Okano

doi:10.1523/ENEURO.0500-20.2021

Article Information

DOI

https://doi.org/10.1523/ENEURO.0500-20.2021

PubMed

33608391

Published By

Society for Neuroscience

History

Received November 21, 2020
Revision received January 27, 2021
Accepted January 30, 2021
Published online February 19, 2021.

Copyright © 2021 Watanabe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

Hirotaka Watanabe¹,
Kent Imaizumi¹,
Tetsuo Cai²,³,
Zhi Zhou¹,³,
Taisuke Tomita² and
Hideyuki Okano¹

¹Department of Physiology, Keio University, School of Medicine, Tokyo, 160-8582, Japan
²Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan
³Research Fellow of Japan Society for the Promotion of Science (JSPS), Tokyo, 102-0083, Japan

Hirotaka Watanabe at hwatanabe{at}keio.jp or Hideyuki Okano at hidokano{at}keio.jp

Author contributions

H.W. designed research; H.W., K.I., and T.C. performed research; H.W. and K.I. analyzed data; H.W. wrote the paper; Z.Z., T.T., and H.O. contributed unpublished reagents/analytic tools.

Disclosures

H.O. is a scientific consultant for SanBio, Co. Ltd., and K Pharma Inc. The other authors declare neither financial nor non-financial competing interests.
Japan Society for the Promotion of Science (JSPS) [15H06587]; Japan Society for the Promotion of Science (JSPS) [17K08668]; Japan Society for the Promotion of Science (JSPS) [19H01015]; Japan Agency for Medical Research and Development (AMED) [15bk0104027h0003]; Japan Agency for Medical Research and Development (AMED) [16bk0104016h0004]; Japan Agency for Medical Research and Development (AMED) [17bk0104016h0005]; Japan Agency for Medical Research and Development (AMED) [15bm0609003h0004]; Japan Agency for Medical Research and Development (AMED) [16bm0609003h0005]; Japan Agency for Medical Research and Development (AMED) [17bm0804003h0001]; Japan Agency for Medical Research and Development (AMED) [18bm0804003h0002]; Japan Agency for Medical Research and Development (AMED) [19bm0804003h0003]; Japan Agency for Medical Research and Development (AMED) [20bm0804003h0104]

Funding

Japan Society for the Promotion of Science (JSPS)
15H06587; 17K08668; 19H01015
Japan Agency for Medical Research and Development (AMED)
15bk0104027h0003; 16bk0104016h0004; 17bk0104016h0005; 15bm0609003h0004; 16bm0609003h0005; 17bm0804003h0001; 18bm0804003h0002; 19bm0804003h0003; 20bm0804003h0104