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New Research, Novel Tools and Methods

Selective activation of resting state networks following focal stimulation in a connectome-based network model of the human brain

Andreas Spiegler, Enrique C.A. Hansen, Christophe Bernard, Anthony R. McIntosh and Viktor K. Jirsa
eNeuro 21 September 2016, ENEURO.0068-16.2016; DOI: https://doi.org/10.1523/ENEURO.0068-16.2016
Andreas Spiegler
1Institut de la Santé et de la Recherche Médical, Aix Marseille Université, Institut de Neurosciences des Systèmes UMR_S 1106, 13005, Marseille, France
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Enrique C.A. Hansen
1Institut de la Santé et de la Recherche Médical, Aix Marseille Université, Institut de Neurosciences des Systèmes UMR_S 1106, 13005, Marseille, France
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Christophe Bernard
1Institut de la Santé et de la Recherche Médical, Aix Marseille Université, Institut de Neurosciences des Systèmes UMR_S 1106, 13005, Marseille, France
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Anthony R. McIntosh
2Rotman Research Institute of Baycrest Center, University of Toronto, Toronto, M6A 2E1, Canada
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Viktor K. Jirsa
1Institut de la Santé et de la Recherche Médical, Aix Marseille Université, Institut de Neurosciences des Systèmes UMR_S 1106, 13005, Marseille, France
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This article has a correction. Please see:

  • Correction: Spiegler et al., Selective Activation of Resting-State Networks following Focal Stimulation in a Connectome-Based Network Model of the Human Brain (eNeuro September/October 2016, 3(5) e0068-16.2016 1-17 http://dx.doi.org/10.1523/ENEURO.0068-16.2016) - October 31, 2016

Abstract

When the brain is stimulated, for example, by sensory inputs or goal-oriented tasks, the brain initially responds with activities in specific areas. The subsequent pattern formation of functional networks is constrained by the structural connectivity (SC) of the brain. The extent to which information is processed over short- or long-range SC is unclear. Whole-brain models based on long-range axonal connections, for example, can partly describe measured functional connectivity dynamics at rest. Here, we study the effect of SC on the network response to stimulation. We use a human whole-brain network model comprising long- and short-range connections. We systematically activate each cortical or thalamic area, and investigate the network response as a function of its short- and long-range SC. We show that when the brain is operating at the edge of criticality, stimulation causes a cascade of network recruitments, collapsing onto a smaller space that is partly constrained by SC. We found both short- and long-range SC essential to reproduce experimental results. In particular, the stimulation of specific areas results in the activation of one or more resting state networks. We suggest that the stimulus-induced brain activity, which may indicate information and cognitive processing, follows specific routes imposed by structural networks explaining the emergence of functional networks. We provide a lookup table linking stimulation targets and functional network activations, potentially useful in diagnostics and treatments with brain stimulation.

Significance Statement Systematic exploration via stimulation of all cortical and subcortical brain areas can only be performed in silico. We have performed a detailed parametric exploration of dynamically responsive networks of a large-scale brain network model to stimulation and developed a stimulation map indicating which brain areas need to be stimulated to place the brain in a particular state at rest. Brain stimulation is one of the upcoming novel tools in the treatment of neurological disorders. The stimulation map will be critical in guiding these studies and allow for the development of theory guided stimulation protocols.

  • : connectivity
  • connectome
  • criticality
  • network modeling
  • resting state
  • stimulation

Footnotes

  • Authors report no conflict of interest.

  • James S. McDonnell Foundation and the European Union Seventh Framework Programme.

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Selective activation of resting state networks following focal stimulation in a connectome-based network model of the human brain
Andreas Spiegler, Enrique C.A. Hansen, Christophe Bernard, Anthony R. McIntosh, Viktor K. Jirsa
eNeuro 21 September 2016, ENEURO.0068-16.2016; DOI: 10.1523/ENEURO.0068-16.2016

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Selective activation of resting state networks following focal stimulation in a connectome-based network model of the human brain
Andreas Spiegler, Enrique C.A. Hansen, Christophe Bernard, Anthony R. McIntosh, Viktor K. Jirsa
eNeuro 21 September 2016, ENEURO.0068-16.2016; DOI: 10.1523/ENEURO.0068-16.2016
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Keywords

  • : connectivity
  • connectome
  • criticality
  • network modeling
  • resting state
  • stimulation

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