Abstract
The organization of neural circuits that form the locomotor central pattern generator (CPG) and provide flexor-extensor and left-right coordination of neuronal activity remains largely unknown. However, significant progress has been made in the molecular/genetic identification of several types of spinal interneurons, including V0 (V0D and V0V sub-types), V1, V2a, V2b, V3, and Shox2, among others. The possible functional roles of these interneurons can be suggested from changes in the locomotor pattern generated in mutant mice lacking particular neuron types. Computational modeling of spinal circuits may complement these studies by bringing together data from different experimental studies and proposing the possible connectivity of these interneurons that may define rhythm generation, flexor-extensor interactions on each side of the cord, and commissural interactions between left and right circuits. This review focuses on the analysis of potential architectures of spinal circuits that can reproduce recent results and suggest common explanations for a series of experimental data on genetically identified spinal interneurons, including the consequences of their genetic ablation, and provide important insights into the organization of spinal CPG and neural control of locomotion.
Significance Statement: We review and analyze together (a) the currently proposed architectures of the central pattern generator (CPG) in the mammalian spinal cord and (b) different classes of genetically identified spinal interneurons. We suggest the possible roles of these interneurons, their connectivity and functions within the spinal circuitry and the CPG, which can simultaneously explain multiple experimental data and provide important insights into the organization and operation of neural circuits in the spinal cord during locomotion.
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