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Research ArticleResearch Article: New Research, Neuronal Excitability

Differential Modes of Action of α1- and α1γ2-Autoantibodies Derived from Patients with GABAAR Encephalitis

Adriana C. M. van Casteren, Frauke Ackermann, Kazi Atikur Rahman, Ewa Andrzejak, Christian Rosenmund, Jakob Kreye, Harald Prüss, Craig C. Garner and Aleksandra Ichkova
eNeuro 29 November 2022, 9 (6) ENEURO.0369-22.2022; https://doi.org/10.1523/ENEURO.0369-22.2022
Adriana C. M. van Casteren
1Neurowissenschaftliches Forschungszentrum (NWFZ), Charité–Universitätsmedizin, Berlin 10117, Germany
2NeuroCure Cluster of Excellence, Charité–Universitätsmedizin, Berlin 10117, Germany
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Frauke Ackermann
3German Center for Neurodegenerative Diseases (DZNE), Berlin 10117, Germany
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Kazi Atikur Rahman
1Neurowissenschaftliches Forschungszentrum (NWFZ), Charité–Universitätsmedizin, Berlin 10117, Germany
4Einstein Center for Neurosciences Berlin, Charité- Universitätsmedizin, Berlin 10117, Germany
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Ewa Andrzejak
3German Center for Neurodegenerative Diseases (DZNE), Berlin 10117, Germany
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Christian Rosenmund
2NeuroCure Cluster of Excellence, Charité–Universitätsmedizin, Berlin 10117, Germany
5Institute of Neurophysiology, Charité–Universitätsmedizin, Berlin 10117, Germany
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Jakob Kreye
3German Center for Neurodegenerative Diseases (DZNE), Berlin 10117, Germany
6Department of Neurology and Experimental Neurology, Charité–Universitätsmedizin, Berlin 10117, Germany
7Department of Pediatric Neurology, Charité–Universitätsmedizin, Berlin 10117, Germany
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Harald Prüss
3German Center for Neurodegenerative Diseases (DZNE), Berlin 10117, Germany
6Department of Neurology and Experimental Neurology, Charité–Universitätsmedizin, Berlin 10117, Germany
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Craig C. Garner
2NeuroCure Cluster of Excellence, Charité–Universitätsmedizin, Berlin 10117, Germany
3German Center for Neurodegenerative Diseases (DZNE), Berlin 10117, Germany
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Aleksandra Ichkova
3German Center for Neurodegenerative Diseases (DZNE), Berlin 10117, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0369-22.2022
PubMed 
36446572
Published By 
Society for Neuroscience
History 
  • Received September 9, 2022
  • Revision received October 24, 2022
  • Accepted October 27, 2022
  • Published online November 29, 2022.
Copyright & Usage 
Copyright © 2022 van Casteren et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Adriana C. M. van Casteren1,2,
  2. Frauke Ackermann3,
  3. Kazi Atikur Rahman1,4,
  4. Ewa Andrzejak3,
  5. Christian Rosenmund2,5,
  6. Jakob Kreye3,6,7,
  7. Harald Prüss3,6,
  8. Craig C. Garner2,3 and
  9. Aleksandra Ichkova3
  1. 1Neurowissenschaftliches Forschungszentrum (NWFZ), Charité–Universitätsmedizin, Berlin 10117, Germany
  2. 2NeuroCure Cluster of Excellence, Charité–Universitätsmedizin, Berlin 10117, Germany
  3. 3German Center for Neurodegenerative Diseases (DZNE), Berlin 10117, Germany
  4. 4Einstein Center for Neurosciences Berlin, Charité- Universitätsmedizin, Berlin 10117, Germany
  5. 5Institute of Neurophysiology, Charité–Universitätsmedizin, Berlin 10117, Germany
  6. 6Department of Neurology and Experimental Neurology, Charité–Universitätsmedizin, Berlin 10117, Germany
  7. 7Department of Pediatric Neurology, Charité–Universitätsmedizin, Berlin 10117, Germany
  1. Correspondence should be addressed to Aleksandra Ichkova at aleksandra.ichkova{at}dzne.de or Craig C. Garner at craig.garner{at}dzne.de.
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Author contributions

  1. Author contributions: A.C.M.v.C., F.A., K.A.R., E.A., C.R., C.C.G., and A.I. designed research; A.C.M.v.C. performed research; J.K. and H.P. contributed unpublished reagents/analytic tools; A.C.M.v.C. and A.I. analyzed data; A.C.M.v.C., F.A., K.A.R., E.A., C.R., J.K., H.P., C.C.G., and A.I. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the German Center for Neurodegenerative Diseases; the Federal Government of Germany (Deutsche Forschungsgemeinschaft) Grants SFB958 (to C.C.G.), EXC-2049-390688087 for the Center of Excellence NeuroCure (to C.C.G.), EXC-2049-390688087 for the Center of Excellence NeuroCure (to F.A.), and PR1274/3-1, PR1274/4-1, and PR1274/5-1 (to H.P.); the Helmholtz Association Grant HIL-A03 (to H.P.); and German Federal Ministry of Education and Research Grant Connect-Generate 01GM1908D (to H.P.).

Funding

  • Deutsche Forschungsgemeinschaft (DFG)

    SFB958; PR1274/3-1; PR1274/4-1; PR1274/5-1
  • NeuroCure Exzellenzcluster (NeuroCure Cluster of Excellence)

    EXC-2049-390688087; EXC-2049-390688087
  • Helmholtz Association (亥姆霍兹联合会致力)

    HIL-A03
  • Bundesministerium für Bildung und Forschung (BMBF)

    01GM1908D

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 29, 2022).

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Differential Modes of Action of α1- and α1γ2-Autoantibodies Derived from Patients with GABAAR Encephalitis
Adriana C. M. van Casteren, Frauke Ackermann, Kazi Atikur Rahman, Ewa Andrzejak, Christian Rosenmund, Jakob Kreye, Harald Prüss, Craig C. Garner, Aleksandra Ichkova
eNeuro 29 November 2022, 9 (6) ENEURO.0369-22.2022; DOI: 10.1523/ENEURO.0369-22.2022

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Differential Modes of Action of α1- and α1γ2-Autoantibodies Derived from Patients with GABAAR Encephalitis
Adriana C. M. van Casteren, Frauke Ackermann, Kazi Atikur Rahman, Ewa Andrzejak, Christian Rosenmund, Jakob Kreye, Harald Prüss, Craig C. Garner, Aleksandra Ichkova
eNeuro 29 November 2022, 9 (6) ENEURO.0369-22.2022; DOI: 10.1523/ENEURO.0369-22.2022
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Keywords

  • autoantibodies
  • autoimmune encephalitis
  • cortical/striatal neurons
  • GABAAR
  • network excitability

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