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Research ArticleResearch Article: New Research, Sensory and Motor Systems

The Developmental Progression of Eight Opsin Spectral Signals Recorded from the Zebrafish Retinal Cone Layer Is Altered by the Timing and Cell Type Expression of Thyroxin Receptor β2 (trβ2) Gain-Of-Function Transgenes

Ralph F. Nelson, Annika Balraj, Tara Suresh, Leah J. Elias, Takeshi Yoshimatsu and Sara S. Patterson
eNeuro 9 November 2022, 9 (6) ENEURO.0326-22.2022; DOI: https://doi.org/10.1523/ENEURO.0326-22.2022
Ralph F. Nelson
1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892
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Annika Balraj
1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892
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Tara Suresh
1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892
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Leah J. Elias
1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892
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Takeshi Yoshimatsu
2Department of Biological Structure, University of Washington, Seattle, WA 98195
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Sara S. Patterson
1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0326-22.2022
PubMed 
36351817
Published By 
Society for Neuroscience
History 
  • Received August 15, 2022
  • Revision received October 27, 2022
  • Accepted November 1, 2022
  • Published online November 9, 2022.
Copyright & Usage 
Copyright © 2022 Nelson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ralph F. Nelson1,
  2. Annika Balraj1,
  3. Tara Suresh1,
  4. Leah J. Elias1,
  5. Takeshi Yoshimatsu2 and
  6. Sara S. Patterson1
  1. 1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892
  2. 2Department of Biological Structure, University of Washington, Seattle, WA 98195
  1. Correspondence should be addressed to Ralph F. Nelson at nelsonr{at}ninds.nih.gov.
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Author contributions

  1. Author contributions: R.F.N., L.J.E., T.Y., and S.S.P. designed research; A.B., T.S., L.J.E., T.Y., and S.S.P. performed research; R.F.N. contributed unpublished reagents/analytic tools; R.F.N., A.B., T.S., L.J.E., T.Y., and S.S.P. analyzed data; R.F.N. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by the Division of Intramural Research of the NIH, NINDS (ZIANS002631 to R.F.N.) and by NIH Grant EY 14358 (to R.O.L. Wong). T.Y.’s research contributions were conducted while in the R.O.L.W. lab at the University of Washington.

  • A. Balraj’s present address: Ophthalmology, School of Medicine, University of California San Francisco, 94143.

  • T. Suresh’s present address: Washington University School of Medicine, St. Louis, MO 63110.

  • L. J. Elias’s present address: Neuroscience, Johns Hopkins Medical School, Baltimore, MD 21205.

  • T. Yoshimatsu’s present address: Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110.

  • S. S. Patterson’s present address: Center for Visual Science, University of Rochester, New York, NY 14627.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NINDS intramural program
  • HHS | NIH | National Eye Institute (NEI)

    EY14356

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The Developmental Progression of Eight Opsin Spectral Signals Recorded from the Zebrafish Retinal Cone Layer Is Altered by the Timing and Cell Type Expression of Thyroxin Receptor β2 (trβ2) Gain-Of-Function Transgenes
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The Developmental Progression of Eight Opsin Spectral Signals Recorded from the Zebrafish Retinal Cone Layer Is Altered by the Timing and Cell Type Expression of Thyroxin Receptor β2 (trβ2) Gain-Of-Function Transgenes
Ralph F. Nelson, Annika Balraj, Tara Suresh, Leah J. Elias, Takeshi Yoshimatsu, Sara S. Patterson
eNeuro 9 November 2022, 9 (6) ENEURO.0326-22.2022; DOI: 10.1523/ENEURO.0326-22.2022

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The Developmental Progression of Eight Opsin Spectral Signals Recorded from the Zebrafish Retinal Cone Layer Is Altered by the Timing and Cell Type Expression of Thyroxin Receptor β2 (trβ2) Gain-Of-Function Transgenes
Ralph F. Nelson, Annika Balraj, Tara Suresh, Leah J. Elias, Takeshi Yoshimatsu, Sara S. Patterson
eNeuro 9 November 2022, 9 (6) ENEURO.0326-22.2022; DOI: 10.1523/ENEURO.0326-22.2022
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Keywords

  • developmental biology
  • ERG
  • opsin absorbance
  • opsin antibodies
  • red cones
  • spectral sensitivity

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