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Research ArticleResearch Article: New Research, Neuronal Excitability

Coordinated Regulation of CB1 Cannabinoid Receptors and Anandamide Metabolism Stabilizes Network Activity during Homeostatic Downscaling

Michael Ye, Sarah K. Monroe, Sean M. Gay, Michael L. Armstrong, Diane E. Youngstrom, Fabio L. Urbina, Stephanie L. Gupton, Nichole Reisdorph and Graham H. Diering
eNeuro 31 October 2022, 9 (6) ENEURO.0276-22.2022; https://doi.org/10.1523/ENEURO.0276-22.2022
Michael Ye
1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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Sarah K. Monroe
1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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Sean M. Gay
2University of North Carolina Neuroscience Center, Chapel Hill, NC 27599
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Michael L. Armstrong
3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
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Diane E. Youngstrom
1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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Fabio L. Urbina
1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
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Stephanie L. Gupton
1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
2University of North Carolina Neuroscience Center, Chapel Hill, NC 27599
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Nichole Reisdorph
3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
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Graham H. Diering
1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
2University of North Carolina Neuroscience Center, Chapel Hill, NC 27599
4Carolina Institute for Developmental Disabilities, Carrboro, NC 27510
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0276-22.2022
PubMed 
36316118
Published By 
Society for Neuroscience
History 
  • Received July 7, 2022
  • Revision received September 20, 2022
  • Accepted September 28, 2022
  • Published online October 31, 2022.
Copyright & Usage 
Copyright © 2022 Ye et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Michael Ye1,
  2. Sarah K. Monroe1,
  3. Sean M. Gay2,
  4. Michael L. Armstrong3,
  5. Diane E. Youngstrom1,
  6. Fabio L. Urbina1,
  7. Stephanie L. Gupton1,2,
  8. Nichole Reisdorph3 and
  9. Graham H. Diering1,2,4
  1. 1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
  2. 2University of North Carolina Neuroscience Center, Chapel Hill, NC 27599
  3. 3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
  4. 4Carolina Institute for Developmental Disabilities, Carrboro, NC 27510
  1. Correspondence should be addressed to Graham H. Diering at graham_diering{at}med.unc.edu.
View Full Text

Author contributions

  1. Author contributions: M.Y. and G.H.D. designed research; M.Y., S.K.M., S.M.G., M.L.A., D.E.Y., and G.H.D. performed research; F.L.U. and S.L.G. contributed unpublished reagents/analytic tools; M.Y., S.K.M., S.M.G., M.L.A., F.L.U., S.L.G., N.R., and G.H.D. analyzed data; M.Y. and G.H.D. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants RF1AG068063 (to G.H.D.) and R01NS112326 (to S.L.G.).

Funding

  • NIH/NIA

    RF1AG068063
  • NIH/NINDS

    R01NS112326

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 31, 2022).

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Oct 202232013
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Total 2022682469339
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Jul 20231011638
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Total 20241441299324
Jan 202589634
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May 20251012716
Jun 20251312220
Jul 20251614425
Aug 2025813321
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Oct 20251919931
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Dec 202533112
Total 20251261562284
Total114444821297
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November/December 2022
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Coordinated Regulation of CB1 Cannabinoid Receptors and Anandamide Metabolism Stabilizes Network Activity during Homeostatic Downscaling
Michael Ye, Sarah K. Monroe, Sean M. Gay, Michael L. Armstrong, Diane E. Youngstrom, Fabio L. Urbina, Stephanie L. Gupton, Nichole Reisdorph, Graham H. Diering
eNeuro 31 October 2022, 9 (6) ENEURO.0276-22.2022; DOI: 10.1523/ENEURO.0276-22.2022

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Coordinated Regulation of CB1 Cannabinoid Receptors and Anandamide Metabolism Stabilizes Network Activity during Homeostatic Downscaling
Michael Ye, Sarah K. Monroe, Sean M. Gay, Michael L. Armstrong, Diane E. Youngstrom, Fabio L. Urbina, Stephanie L. Gupton, Nichole Reisdorph, Graham H. Diering
eNeuro 31 October 2022, 9 (6) ENEURO.0276-22.2022; DOI: 10.1523/ENEURO.0276-22.2022
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Keywords

  • anandamide
  • cannabinoid receptor
  • endocannabinoid system
  • homeostatic scaling
  • network activity
  • synaptic plasticity

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