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Research ArticleResearch Article: New Research, Disorders of the Nervous System

A Model for the Propagation of Seizure Activity in Normal Brain Tissue

Damien Depannemaecker, Mallory Carlu, Jules Bouté and Alain Destexhe
eNeuro 2 November 2022, 9 (6) ENEURO.0234-21.2022; DOI: https://doi.org/10.1523/ENEURO.0234-21.2022
Damien Depannemaecker
French National Centre for Scientific Research (CNRS), Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, 91198 Gif sur Yvette, France
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Mallory Carlu
French National Centre for Scientific Research (CNRS), Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, 91198 Gif sur Yvette, France
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Jules Bouté
French National Centre for Scientific Research (CNRS), Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, 91198 Gif sur Yvette, France
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Alain Destexhe
French National Centre for Scientific Research (CNRS), Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, 91198 Gif sur Yvette, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0234-21.2022
PubMed 
36323513
Published By 
Society for Neuroscience
History 
  • Received May 19, 2021
  • Revision received September 23, 2022
  • Accepted September 29, 2022
  • Published online November 2, 2022.
Copyright & Usage 
Copyright © 2022 Depannemaecker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Damien Depannemaecker*,
  2. Mallory Carlu*,
  3. Jules Bouté and
  4. Alain Destexhe
  1. French National Centre for Scientific Research (CNRS), Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, 91198 Gif sur Yvette, France
  1. Correspondence should be addressed to Damien Depannemaecker at damien.depannemaecker{at}univ-amu.fr or Alain Destexhe at alain.destexhe{at}cnrs.fr.
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Author contributions

  1. Author contributions: D.D., M.C., and A.D. designed research; D.D., M.C., and J.B. performed research; D.D. and M.C. contributed unpublished reagents/analytic tools; D.D., M.C., and J.B. analyzed data; D.D. and M.C. wrote the paper.

  2. ↵* D.D. and M.C. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was funded from the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project SGA3) and the Centre National de la Recherche Scientifique (France).

Funding

  • EC | Horizon 2020 (EU Framework Programme for Research and Innovation)

    945539

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eneuro: 9 (6)
eNeuro
Vol. 9, Issue 6
November/December 2022
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A Model for the Propagation of Seizure Activity in Normal Brain Tissue
Damien Depannemaecker, Mallory Carlu, Jules Bouté, Alain Destexhe
eNeuro 2 November 2022, 9 (6) ENEURO.0234-21.2022; DOI: 10.1523/ENEURO.0234-21.2022

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A Model for the Propagation of Seizure Activity in Normal Brain Tissue
Damien Depannemaecker, Mallory Carlu, Jules Bouté, Alain Destexhe
eNeuro 2 November 2022, 9 (6) ENEURO.0234-21.2022; DOI: 10.1523/ENEURO.0234-21.2022
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Keywords

  • computational modeling
  • epilepsy
  • inhibitory population
  • seizure control
  • seizure propagation
  • spiking network model

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