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Research ArticleResearch Article: New Research, Development

A Prospective Study of the Impact of Severe Childhood Deprivation on Brain White Matter in Adult Adoptees: Widespread Localized Reductions in Volume But Unaffected Microstructural Organization

Nuria K. Mackes, Mitul A. Mehta, Ahmad Beyh, Richard O. Nkrumah, Dennis Golm, Sagari Sarkar, Graeme Fairchild, Flavio Dell’Acqua, Edmund J. S. Sonuga-Barke and on behalf of the ERA Young Adult Follow-Up Team
eNeuro 14 November 2022, 9 (6) ENEURO.0188-22.2022; DOI: https://doi.org/10.1523/ENEURO.0188-22.2022
Nuria K. Mackes
1Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
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Mitul A. Mehta
2Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
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Ahmad Beyh
3Department of Forensic & Neurodevelopmental Sciences. Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
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  • ORCID record for Ahmad Beyh
Richard O. Nkrumah
4Department of Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim J5 68159, Germany
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Dennis Golm
5Centre for Innovation in Mental Health, School of Psychology, University of Southampton, Southampton SO17 1PS, United Kingdom
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Sagari Sarkar
6Cognitive Neuroscience & Neuropsychiatry, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
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Graeme Fairchild
7Department of Psychology, University of Bath, Bath BA2 7AY, United Kingdom
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Flavio Dell’Acqua
3Department of Forensic & Neurodevelopmental Sciences. Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
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Edmund J. S. Sonuga-Barke
8Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
9Department of Child & Adolescent Psychiatry, Aarhus University, Aarhus 8000, Denmark
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0188-22.2022
PubMed 
36376082
Published By 
Society for Neuroscience
History 
  • Received May 9, 2022
  • Revision received July 7, 2022
  • Accepted July 12, 2022
  • Published online November 14, 2022.
Copyright & Usage 
Copyright © 2022 Mackes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nuria K. Mackes1,
  2. Mitul A. Mehta2,
  3. Ahmad Beyh3,
  4. Richard O. Nkrumah4,
  5. Dennis Golm5,
  6. Sagari Sarkar6,
  7. Graeme Fairchild7,
  8. Flavio Dell’Acqua3,*,
  9. Edmund J. S. Sonuga-Barke8,9,*,
  10. on behalf of the ERA Young Adult Follow-Up Team†
  1. 1Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  2. 2Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  3. 3Department of Forensic & Neurodevelopmental Sciences. Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  4. 4Department of Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim J5 68159, Germany
  5. 5Centre for Innovation in Mental Health, School of Psychology, University of Southampton, Southampton SO17 1PS, United Kingdom
  6. 6Cognitive Neuroscience & Neuropsychiatry, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
  7. 7Department of Psychology, University of Bath, Bath BA2 7AY, United Kingdom
  8. 8Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom
  9. 9Department of Child & Adolescent Psychiatry, Aarhus University, Aarhus 8000, Denmark
  1. Correspondence should be addressed to Edmund J. S. Sonuga-Barke at edmund.sonuga-barke{at}kcl.ac.uk or Nuria K. Mackes at nuria.mackes{at}kcl.ac.uk.
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Author contributions

  1. Author contributions: M.A.M., G.F., F.D., and E.J.S.S.-B. designed research; N.K.M., D.G., and S.S. performed research; N.K.M., A.B., R.O.N., D.G., and S.S. analyzed data; N.K.M., M.A.M., A.B., R.O.N., D.G., S.S., G.F., F.D., and E.J.S.S.-B. wrote the paper.

  2. ↵* F.D. and E.J.S.S.-B. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • The ERABIS was supported by the Medical Research Council Grant MR/K022474/1. Economic and Social Research Council Grant RES-062-23-3300 supported the Young Adult Follow-Up. This work was supported by the National Institute for Health Research (NIHR) Clinical Research Network. M.A.M. was supported in part by the NIHR Biomedical Research Centre at South London, Maudsley National Health Service (NHS) Foundation Trust, and King’s College London.

  • ↵† The ERA Young Adult Follow-Up Team is Edmund Sonuga-Barke, Mark Kennedy, Jana Kreppner, Nicky Knights, Robert Kumsta, Barbara Maughan, and Wolff Schlotz.

Funding

  • UKRI | Medical Research Council (MRC)

    MR/K022474/1
  • Economic and Social Research Council (ESRC)

    RES-062-23-3300

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A Prospective Study of the Impact of Severe Childhood Deprivation on Brain White Matter in Adult Adoptees: Widespread Localized Reductions in Volume But Unaffected Microstructural Organization
Nuria K. Mackes, Mitul A. Mehta, Ahmad Beyh, Richard O. Nkrumah, Dennis Golm, Sagari Sarkar, Graeme Fairchild, Flavio Dell’Acqua, Edmund J. S. Sonuga-Barke, on behalf of the ERA Young Adult Follow-Up Team
eNeuro 14 November 2022, 9 (6) ENEURO.0188-22.2022; DOI: 10.1523/ENEURO.0188-22.2022

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A Prospective Study of the Impact of Severe Childhood Deprivation on Brain White Matter in Adult Adoptees: Widespread Localized Reductions in Volume But Unaffected Microstructural Organization
Nuria K. Mackes, Mitul A. Mehta, Ahmad Beyh, Richard O. Nkrumah, Dennis Golm, Sagari Sarkar, Graeme Fairchild, Flavio Dell’Acqua, Edmund J. S. Sonuga-Barke, on behalf of the ERA Young Adult Follow-Up Team
eNeuro 14 November 2022, 9 (6) ENEURO.0188-22.2022; DOI: 10.1523/ENEURO.0188-22.2022
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Keywords

  • brain imaging
  • early adversity
  • institutional deprivation
  • plasticity
  • tractography
  • white matter structure

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