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Research ArticleResearch Article: New Research, Development

Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1

Annemiek A. Van Berkel, Frank Koopmans, Miguel Angel Gonzalez-Lozano, Hanna C. A. Lammertse, Femke Feringa, Julien Bryois, Patrick F. Sullivan, August B. Smit, Ruud F. Toonen and Matthijs Verhage
eNeuro 18 October 2022, 9 (6) ENEURO.0186-22.2022; https://doi.org/10.1523/ENEURO.0186-22.2022
Annemiek A. Van Berkel
1Department Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
3Functional Genomics, Department of Human Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam UMC, Amsterdam 1081 HV, The Netherlands
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Frank Koopmans
1Department Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
2Department Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
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  • ORCID record for Frank Koopmans
Miguel Angel Gonzalez-Lozano
2Department Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
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  • ORCID record for Miguel Angel Gonzalez-Lozano
Hanna C. A. Lammertse
1Department Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
3Functional Genomics, Department of Human Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam UMC, Amsterdam 1081 HV, The Netherlands
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Femke Feringa
3Functional Genomics, Department of Human Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam UMC, Amsterdam 1081 HV, The Netherlands
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  • ORCID record for Femke Feringa
Julien Bryois
5Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden
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Patrick F. Sullivan
4University of North Carolina Center for Psychiatric Genomics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160
5Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden
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August B. Smit
2Department Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
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Ruud F. Toonen
1Department Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
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Matthijs Verhage
1Department Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
3Functional Genomics, Department of Human Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam UMC, Amsterdam 1081 HV, The Netherlands
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0186-22.2022
PubMed 
36257704
Published By 
Society for Neuroscience
History 
  • Received May 9, 2022
  • Revision received June 27, 2022
  • Accepted July 14, 2022
  • Published online October 18, 2022.
Copyright & Usage 
Copyright © 2022 Van Berkel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Annemiek A. Van Berkel1,3,
  2. Frank Koopmans1,2,
  3. Miguel Angel Gonzalez-Lozano2,
  4. Hanna C. A. Lammertse1,3,
  5. Femke Feringa3,
  6. Julien Bryois5,
  7. Patrick F. Sullivan4,5,
  8. August B. Smit2,
  9. Ruud F. Toonen1 and
  10. Matthijs Verhage1,3
  1. 1Department Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
  2. 2Department Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
  3. 3Functional Genomics, Department of Human Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam UMC, Amsterdam 1081 HV, The Netherlands
  4. 4University of North Carolina Center for Psychiatric Genomics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160
  5. 5Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden
  1. Correspondence should be addressed to M. Verhage at m.verhage{at}vu.nl.
View Full Text

Author contributions

  1. Author contributions: A.A.V.B., R.F.T., and M.V. designed research; A.A.V.B., H.C.A.L., and F.F. performed research; A.A.V.B., F.K., M.A.G.-L., J.B., P.F.S., and A.B.S. analyzed data; A.A.V.B. and M.V. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the European Union ERC Advanced Grant 322966 (to M.V.), the Horizon 2020 Grant COSYN (RIA Grant Agreement 610307; to M.V. and P.F.S.), the Orphan Disease Center/Million Dollar Bike Ride Grant MDBR-20-136-STXBP1 (to M.V.), the Lundbeckfondsen Grant R277-2018-802 (to M.V.), and the Swedish Research Council Grant 538-2013-8865 (to P.F.S.).

Funding

  • EC | European Research Council (ERC)

    322966
  • EC | Horizon 2020 Framework Programme (H2020)

    610307
  • Penn | Penn Med | Orphan Disease Center, Perelman School of Medicine, University of Pennsylvania (ODC)

    MDBR-20-136-STXBP1
  • Lundbeckfonden (Lundbeck Foundation)

    R277-2018-802
  • Swedish research council

    538-2013-8865

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 18, 2022).

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Total 2026951041242
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Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1
Annemiek A. Van Berkel, Frank Koopmans, Miguel Angel Gonzalez-Lozano, Hanna C. A. Lammertse, Femke Feringa, Julien Bryois, Patrick F. Sullivan, August B. Smit, Ruud F. Toonen, Matthijs Verhage
eNeuro 18 October 2022, 9 (6) ENEURO.0186-22.2022; DOI: 10.1523/ENEURO.0186-22.2022

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Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1
Annemiek A. Van Berkel, Frank Koopmans, Miguel Angel Gonzalez-Lozano, Hanna C. A. Lammertse, Femke Feringa, Julien Bryois, Patrick F. Sullivan, August B. Smit, Ruud F. Toonen, Matthijs Verhage
eNeuro 18 October 2022, 9 (6) ENEURO.0186-22.2022; DOI: 10.1523/ENEURO.0186-22.2022
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Keywords

  • MUNC18-1
  • neurodegeneration
  • neurodevelopment
  • proteomics
  • synapse
  • transcriptomics

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