Article Figures & Data
Figures
- Figure 1.
Behavioral effects of autobiographical training. A, Diagram of the experimental design. B, Training increases the number of odor-evoked recalls. Black symbols are PRE data and red symbols are POST data. White-filled symbols are control subjects and gray-filled symbols are training subjects. C, Post-training recall improvement generalizes to untrained odors. D, Training improves voluntary recalls in a significant proportion of subjects. *p < 0.05.
- Figure 2.
Autobiographical training increases anterior default mode network connectivity. A, Horizontal, coronal, and sagittal sections showing the part of right medio-dorsal thalamus (yellow/red) with increased connectivity with anterior DMN (blue) after training. The standard coordinates of the identified cluster in the medio-dorsal thalamus are: MAX X (vox):20, MAX Y:27, MAX Z: 22, COG X: 19.2, COG Y: 27.2, COG Z: 22. Range for z scores is between 3 and 10, and range for p values is between 0.05 and 0.001. B, Summary data showing increased connectivity between right thalamus and anterior DMN after training (gray-filled symbols) compared with controls (white-filled symbols). C, Positive correlation between change in resting-state connectivity and change in the number of odor-evoked recalls.
- Figure 3.
Sensorimotor network connectivity and improved voluntary memory after training. A, Clusters (green) within the sensorimotor network (blue) that negatively correlate with voluntary memory score. B, Subject-specific z score connectivity within the sensorimotor network in the training group and the control group. C, Invers (negative) correlation between sensorimotor connectivity and voluntary memory scores across both training and control groups, r = −0.5, p < 0.0001. Gray symbols represent experimental (training) subjects.
- Figure 4.
Correlation between TNFα and connectivity in the sensorimotor network. A, Horizontal, coronal, and sagittal sections showing the part of motor cortex (green) for which the connectivity with the rest of the sensorimotor network (blue) correlates with TNFα levels. B, Summary data showing decreased TNFα levels after training (p = 0.01) but not after control intervention (p = 0.6). C, Positive correlation between resting-state connectivity in the sensorimotor network and TNFα levels. Red symbols, training; gray symbols, control.
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