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Research ArticleResearch Article: New Research, Disorders of the Nervous System

The Mitochondrial Enzyme 17βHSD10 Modulates Ischemic and Amyloid-β-Induced Stress in Primary Mouse Astrocytes

Vanya Metodieva, Terry Smith and Frank Gunn-Moore
eNeuro 12 September 2022, 9 (5) ENEURO.0040-22.2022; https://doi.org/10.1523/ENEURO.0040-22.2022
Vanya Metodieva
1Medical and Biological Sciences Building, School of Biology, North Haugh, University of St Andrews, St Andrews, Fife KY16 9TF, Scotland, United Kingdom
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Terry Smith
2Biomolecular Sciences Building, School of Biology, North Haugh, University of St Andrews, St Andrews, Fife KY16 9TF, Scotland, United Kingdom
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Frank Gunn-Moore
2Biomolecular Sciences Building, School of Biology, North Haugh, University of St Andrews, St Andrews, Fife KY16 9TF, Scotland, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0040-22.2022
PubMed 
36096650
Published By 
Society for Neuroscience
History 
  • Received January 16, 2022
  • Revision received August 24, 2022
  • Accepted August 31, 2022
  • Published online September 12, 2022.
Copyright & Usage 
Copyright © 2022 Metodieva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Vanya Metodieva1,
  2. Terry Smith2 and
  3. Frank Gunn-Moore2
  1. 1Medical and Biological Sciences Building, School of Biology, North Haugh, University of St Andrews, St Andrews, Fife KY16 9TF, Scotland, United Kingdom
  2. 2Biomolecular Sciences Building, School of Biology, North Haugh, University of St Andrews, St Andrews, Fife KY16 9TF, Scotland, United Kingdom
  1. Correspondence should be addressed to Vanya Metodieva at vvm{at}st-andrews.ac.uk or Frank Gunn-Moore at fjg1{at}st-andrews.ac.uk.
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Author contributions

  1. Author contributions: V.M., T.S., and F.G-M designed research; V.M. performed research; V.M. analyzed data; V.M., T.S., and F.G.-M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Alzheimer’s Society and RS Macdonald Charitable Trust.

Funding

  • Alzheimer's Society

  • RS Macdonald charitable trust

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 12, 2022).

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Jul 20251210221
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Total 20251141268295
Jan 20261117029
Feb 20261428937
Mar 20260214
Total 20262548070
Total85547731470
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eneuro: 9 (5)
eNeuro
Vol. 9, Issue 5
September/October 2022
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The Mitochondrial Enzyme 17βHSD10 Modulates Ischemic and Amyloid-β-Induced Stress in Primary Mouse Astrocytes
Vanya Metodieva, Terry Smith, Frank Gunn-Moore
eNeuro 12 September 2022, 9 (5) ENEURO.0040-22.2022; DOI: 10.1523/ENEURO.0040-22.2022

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The Mitochondrial Enzyme 17βHSD10 Modulates Ischemic and Amyloid-β-Induced Stress in Primary Mouse Astrocytes
Vanya Metodieva, Terry Smith, Frank Gunn-Moore
eNeuro 12 September 2022, 9 (5) ENEURO.0040-22.2022; DOI: 10.1523/ENEURO.0040-22.2022
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Keywords

  • 17β-hydroxysteroid dehydrogenase type 10
  • Alzheimer’s disease
  • astrocytes
  • ischemia
  • metabolism
  • mitochondria

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