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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina

Christie K. Campla, Ulisse Bocchero, Ryan Strickland, Jacob Nellissery, Jayshree Advani, Irina Ignatova, Dhiraj Srivastava, Angel M. Aponte, Yuchen Wang, Jessica Gumerson, Kirill Martemyanov, Nikolai O. Artemyev, Johan Pahlberg and Anand Swaroop
eNeuro 30 September 2022, 9 (5) ENEURO.0348-22.2022; DOI: https://doi.org/10.1523/ENEURO.0348-22.2022
Christie K. Campla
1Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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  • ORCID record for Christie K. Campla
Ulisse Bocchero
1Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
2Photoreceptor Physiology Group, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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Ryan Strickland
1Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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Jacob Nellissery
1Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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Jayshree Advani
1Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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Irina Ignatova
2Photoreceptor Physiology Group, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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Dhiraj Srivastava
3Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Angel M. Aponte
4Proteomics Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
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Yuchen Wang
5Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458
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Jessica Gumerson
1Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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Kirill Martemyanov
5Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458
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Nikolai O. Artemyev
3Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242
6Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Johan Pahlberg
2Photoreceptor Physiology Group, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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Anand Swaroop
1Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0348-22.2022
PubMed 
36180221
Published By 
Society for Neuroscience
History 
  • Received August 29, 2022
  • Accepted September 23, 2022
  • Published online September 30, 2022.
Copyright & Usage 
Copyright © 2022 Campla et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Christie K. Campla1,*,
  2. Ulisse Bocchero1,2,*,
  3. Ryan Strickland1,
  4. Jacob Nellissery1,
  5. Jayshree Advani1,
  6. Irina Ignatova2,
  7. Dhiraj Srivastava3,
  8. Angel M. Aponte4,
  9. Yuchen Wang5,
  10. Jessica Gumerson1,
  11. Kirill Martemyanov5,
  12. Nikolai O. Artemyev3,6,
  13. Johan Pahlberg2 and
  14. Anand Swaroop1
  1. 1Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
  2. 2Photoreceptor Physiology Group, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
  3. 3Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  4. 4Proteomics Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
  5. 5Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458
  6. 6Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  1. Correspondence should be addressed to Anand Swaroop at swaroopa{at}nei.nih.gov or Johan Pahlberg at johan.pahlberg{at}nih.gov.
  • C. K. Campla’s present address: Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195.

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Author contributions

  1. Author contributions: A.S., C.K.C., and J.P. designed research; C.K.C., U.B., R.S., J.N., D.S., A.M.A., Y.W., and J.G. performed research; I.I., D.S., A.M.A., K.M., and N.O.A. contributed unpublished reagents/analytic tools; A.S., C.K.C., U.B., J.N., J.A., I.I., D.S., J.G., K.M., N.O.A., and J.P. analyzed data; A.S., C.K.C., U.B., and N.O.A. wrote the paper.

  2. ↵* C.K.C. and U.B. contributed equally to this work.

  • C. K. Campla’s present address: Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Eye Institute (NEI) Intramural Research Program Grants EY000450 and EY000546 (to A.S.), EY12682 and EY10843 (to N.O.A.), EY018139 and EY028033 (to K.A.M.), K99EY030554 (to Y.W.); National Institute of Dental and Craniofacial Research/National Institute of Neurological Disorders and Stroke/NEI Grants 100000072 and 100000065 (to J.P.); and the Oskar Huttunen Foundation (to I.I.).

Funding

  • HHS | NIH | National Eye Institute (NEI)

    ZIAEY000450; ZIAEY000546; R01EY12682; R01EY10843; R01EY018139; R01EY028033; K99EY030554
  • HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

  • Oskar Huttunen Foundation

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Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina
Christie K. Campla, Ulisse Bocchero, Ryan Strickland, Jacob Nellissery, Jayshree Advani, Irina Ignatova, Dhiraj Srivastava, Angel M. Aponte, Yuchen Wang, Jessica Gumerson, Kirill Martemyanov, Nikolai O. Artemyev, Johan Pahlberg, Anand Swaroop
eNeuro 30 September 2022, 9 (5) ENEURO.0348-22.2022; DOI: 10.1523/ENEURO.0348-22.2022

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Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina
Christie K. Campla, Ulisse Bocchero, Ryan Strickland, Jacob Nellissery, Jayshree Advani, Irina Ignatova, Dhiraj Srivastava, Angel M. Aponte, Yuchen Wang, Jessica Gumerson, Kirill Martemyanov, Nikolai O. Artemyev, Johan Pahlberg, Anand Swaroop
eNeuro 30 September 2022, 9 (5) ENEURO.0348-22.2022; DOI: 10.1523/ENEURO.0348-22.2022
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Keywords

  • G-protein
  • phototransduction
  • rod photoreceptor
  • rod-rod bipolar signaling
  • transducin translocation
  • vision

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