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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Blood–Brain Barrier Disruption in Preclinical Mouse Models of Stroke Can Be an Experimental Artifact Caused by Craniectomy

Che-Wei Liu, Eric Yuhsiang Wang, Hwai-Lee Wang, Kate Hsiurong Liao, Hsiao-Yun Chen, Hank Szuhan Chen and Ted Weita Lai
eNeuro 12 October 2022, 9 (5) ENEURO.0343-22.2022; DOI: https://doi.org/10.1523/ENEURO.0343-22.2022
Che-Wei Liu
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan
2School of Medicine, China Medical University, Taichung 404333, Taiwan
3Department of Neurosurgery, Taipei Veterans General Hospital, Taipei 112201, Taiwan
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Eric Yuhsiang Wang
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan
2School of Medicine, China Medical University, Taichung 404333, Taiwan
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Hwai-Lee Wang
4Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404333, Taiwan
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Kate Hsiurong Liao
4Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404333, Taiwan
5Department of Anesthesiology, China Medical University Hospital, Taichung 404327, Taiwan
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  • ORCID record for Kate Hsiurong Liao
Hsiao-Yun Chen
4Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404333, Taiwan
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Hank Szuhan Chen
2School of Medicine, China Medical University, Taichung 404333, Taiwan
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Ted Weita Lai
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan
2School of Medicine, China Medical University, Taichung 404333, Taiwan
4Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404333, Taiwan
6Drug Development Center, China Medical University, Taichung 404333, Taiwan
7Translational Medicine Research Center, China Medical University Hospital, Taichung 404327, Taiwan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0343-22.2022
PubMed 
36224001
Published By 
Society for Neuroscience
History 
  • Received August 25, 2022
  • Revision received October 6, 2022
  • Accepted October 10, 2022
  • Published online October 12, 2022.
Copyright & Usage 
Copyright © 2022 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Che-Wei Liu1,2,3,*,
  2. Eric Yuhsiang Wang1,2,*,
  3. Hwai-Lee Wang4,
  4. Kate Hsiurong Liao4,5,
  5. Hsiao-Yun Chen4,
  6. Hank Szuhan Chen2 and
  7. Ted Weita Lai1,2,4,6,7
  1. 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan
  2. 2School of Medicine, China Medical University, Taichung 404333, Taiwan
  3. 3Department of Neurosurgery, Taipei Veterans General Hospital, Taipei 112201, Taiwan
  4. 4Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404333, Taiwan
  5. 5Department of Anesthesiology, China Medical University Hospital, Taichung 404327, Taiwan
  6. 6Drug Development Center, China Medical University, Taichung 404333, Taiwan
  7. 7Translational Medicine Research Center, China Medical University Hospital, Taichung 404327, Taiwan
  1. Correspondence should be addressed to Ted Weita Lai at ted.weita{at}me.com.
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Author contributions

  1. Author contributions: C.-W.L., E.Y.W., H.-L.W., K.H.L., H.-Y.C., and T.W.L. designed research; C.-W.L., E.Y.W., H.-L.W., H.-Y.C., and H.S.C. performed research; C.-W.L., E.Y.W., and T.W.L. analyzed data; C.-W.L. and T.W.L. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This study was supported by research grants from the China Medical University (Grant CMU101-NSC-03-2), the Ministry of Science and Technology (Grant MOST109-2320-B-039-010), the National Health Research Institutes (Grant NHRI-EX111-10803NI), and the Drug Development Center, China Medical University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan. C.-W.L. and E.Y.W. were supported by undergraduate student research awards from the Ministry of Science and Technology (Grants MOST105-2815-C-039-046-B, MOST106-2813-C-039-066-B, and MOST108-2813-C-039-125-B to C.-W.L.; Grant MOST110-2813-C-039-027-B to E.Y.W.) and by a Long-Term Scholarship for Gifted Students from the Hsing Tian Kung Culture and Education Development Foundation (to E.Y.W.).

  • ↵* C.-W.L. and E.Y.W. are co-first authors.

Funding

  • China Medical University, Taiwan (CMU)

    CMU101-NSC-03-2
  • Ministry of Science and Technology, Taiwan (MOST)

    MOST109-2320-B-039-010
  • National Health Research Institutes (NHRI)

    NHRI-EX111-10803NI

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  • You are viewing the most recent version of this article.
  • previous version (October 12, 2022).

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Blood–Brain Barrier Disruption in Preclinical Mouse Models of Stroke Can Be an Experimental Artifact Caused by Craniectomy
Che-Wei Liu, Eric Yuhsiang Wang, Hwai-Lee Wang, Kate Hsiurong Liao, Hsiao-Yun Chen, Hank Szuhan Chen, Ted Weita Lai
eNeuro 12 October 2022, 9 (5) ENEURO.0343-22.2022; DOI: 10.1523/ENEURO.0343-22.2022

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Blood–Brain Barrier Disruption in Preclinical Mouse Models of Stroke Can Be an Experimental Artifact Caused by Craniectomy
Che-Wei Liu, Eric Yuhsiang Wang, Hwai-Lee Wang, Kate Hsiurong Liao, Hsiao-Yun Chen, Hank Szuhan Chen, Ted Weita Lai
eNeuro 12 October 2022, 9 (5) ENEURO.0343-22.2022; DOI: 10.1523/ENEURO.0343-22.2022
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Keywords

  • blood–brain barrier
  • cerebral edema
  • dMCAO
  • mice
  • preclinical model
  • stroke

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