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Research ArticleResearch Article: New Research, Cognition and Behavior

Perinatal Morphine Exposure Leads to Sex-Dependent Executive Function Deficits and Microglial Changes in Mice

Brittany L. Smith, Tess A. Guzman, Alexander H. Brendle, Collin J. Laaker, Alexis Ford, Adam R. Hiltz, Junfang Zhao, Kenneth D. R. Setchell and Teresa M. Reyes
eNeuro 10 October 2022, 9 (5) ENEURO.0238-22.2022; DOI: https://doi.org/10.1523/ENEURO.0238-22.2022
Brittany L. Smith
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
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Tess A. Guzman
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
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Alexander H. Brendle
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
2College of Nursing, University of Cincinnati, Cincinnati, Ohio 45221
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Collin J. Laaker
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
3Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53705
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Alexis Ford
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
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Adam R. Hiltz
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
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Junfang Zhao
4Clinical Mass Spectrometry Laboratory, Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3026
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Kenneth D. R. Setchell
4Clinical Mass Spectrometry Laboratory, Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3026
5Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
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Teresa M. Reyes
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
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eneuro: 9 (5)
eNeuro
Vol. 9, Issue 5
September/October 2022
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Perinatal Morphine Exposure Leads to Sex-Dependent Executive Function Deficits and Microglial Changes in Mice
Brittany L. Smith, Tess A. Guzman, Alexander H. Brendle, Collin J. Laaker, Alexis Ford, Adam R. Hiltz, Junfang Zhao, Kenneth D. R. Setchell, Teresa M. Reyes
eNeuro 10 October 2022, 9 (5) ENEURO.0238-22.2022; DOI: 10.1523/ENEURO.0238-22.2022

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Perinatal Morphine Exposure Leads to Sex-Dependent Executive Function Deficits and Microglial Changes in Mice
Brittany L. Smith, Tess A. Guzman, Alexander H. Brendle, Collin J. Laaker, Alexis Ford, Adam R. Hiltz, Junfang Zhao, Kenneth D. R. Setchell, Teresa M. Reyes
eNeuro 10 October 2022, 9 (5) ENEURO.0238-22.2022; DOI: 10.1523/ENEURO.0238-22.2022
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Keywords

  • amygdala
  • executive function
  • Microglia
  • prefrontal cortex
  • prenatal opioid
  • social behavior

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