Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro

eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Cognition and Behavior

Perinatal Morphine Exposure Leads to Sex-Dependent Executive Function Deficits and Microglial Changes in Mice

Brittany L. Smith, Tess A. Guzman, Alexander H. Brendle, Collin J. Laaker, Alexis Ford, Adam R. Hiltz, Junfang Zhao, Kenneth D. R. Setchell and Teresa M. Reyes
eNeuro 10 October 2022, 9 (5) ENEURO.0238-22.2022; DOI: https://doi.org/10.1523/ENEURO.0238-22.2022
Brittany L. Smith
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Brittany L. Smith
Tess A. Guzman
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexander H. Brendle
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
2College of Nursing, University of Cincinnati, Cincinnati, Ohio 45221
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Collin J. Laaker
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
3Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53705
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexis Ford
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adam R. Hiltz
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Junfang Zhao
4Clinical Mass Spectrometry Laboratory, Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3026
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kenneth D. R. Setchell
4Clinical Mass Spectrometry Laboratory, Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3026
5Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Teresa M. Reyes
1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0238-22.2022
PubMed 
36216505
Published By 
Society for Neuroscience
History 
  • Received June 20, 2022
  • Revision received August 19, 2022
  • Accepted August 29, 2022
  • Published online October 10, 2022.
Copyright & Usage 
Copyright © 2022 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Brittany L. Smith1,
  2. Tess A. Guzman1,
  3. Alexander H. Brendle1,2,
  4. Collin J. Laaker1,3,
  5. Alexis Ford1,
  6. Adam R. Hiltz1,
  7. Junfang Zhao4,
  8. Kenneth D. R. Setchell4,5 and
  9. Teresa M. Reyes1
  1. 1Department of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, Ohio 45267
  2. 2College of Nursing, University of Cincinnati, Cincinnati, Ohio 45221
  3. 3Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53705
  4. 4Clinical Mass Spectrometry Laboratory, Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3026
  5. 5Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
  1. Correspondence should be addressed to Brittany L. Smith at smithb103{at}nku.edu.
View Full Text

Author contributions

  1. Author contributions: B.L.S., C.J.L., and T.M.R. designed research; B.L.S., T.A.G., A.H.B., C.J.L., A.F., J.Z., and K.D.R.S. performed research; A.R.H. and K.D.R.S. contributed unpublished reagents/analytic tools; B.L.S., C.J.L., and J.Z. analyzed data; B.L.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by National Institutes of Health/National Institute on Drug Abuse Grants K99 DA049908 (to B.L.S.) and R21-DA-049253 (to T.M.R.).

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    K99 DA049908; R21 DA049253

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 10, 2022).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2023-03-28
to
E.g., 2023-03-28

Article usage: October 2022 to March 2023

AbstractFullPdf
Oct 2022591389211
Nov 20225421175
Dec 20221115854
Total 2022656758340
Jan 2023112742
Feb 20231212341
Mar 2023525539
Total 202318505122
Total6741263462
Back to top

In this issue

eneuro: 9 (5)
eNeuro
Vol. 9, Issue 5
September/October 2022
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Perinatal Morphine Exposure Leads to Sex-Dependent Executive Function Deficits and Microglial Changes in Mice
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Perinatal Morphine Exposure Leads to Sex-Dependent Executive Function Deficits and Microglial Changes in Mice
Brittany L. Smith, Tess A. Guzman, Alexander H. Brendle, Collin J. Laaker, Alexis Ford, Adam R. Hiltz, Junfang Zhao, Kenneth D. R. Setchell, Teresa M. Reyes
eNeuro 10 October 2022, 9 (5) ENEURO.0238-22.2022; DOI: 10.1523/ENEURO.0238-22.2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Perinatal Morphine Exposure Leads to Sex-Dependent Executive Function Deficits and Microglial Changes in Mice
Brittany L. Smith, Tess A. Guzman, Alexander H. Brendle, Collin J. Laaker, Alexis Ford, Adam R. Hiltz, Junfang Zhao, Kenneth D. R. Setchell, Teresa M. Reyes
eNeuro 10 October 2022, 9 (5) ENEURO.0238-22.2022; DOI: 10.1523/ENEURO.0238-22.2022
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
    • Author Response
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • amygdala
  • executive function
  • Microglia
  • prefrontal cortex
  • prenatal opioid
  • social behavior

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins
  • Impaired AMPARs Translocation into Dendritic Spines with Motor Skill Learning in the Fragile X Mouse Model
  • The Mobility of Neurofilaments in Mature Myelinated Axons of Adult Mice
Show more Research Article: New Research

Cognition and Behavior

  • Deciding while acting - Mid-movement decisions are more strongly affected by action probability than reward amount
  • Environment Enrichment Facilitates Long-Term Memory Consolidation Through Behavioral Tagging
  • Effects of cortical FoxP1 knockdowns on learned song preference in female zebra finches
Show more Cognition and Behavior

Subjects

  • Cognition and Behavior

  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.