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Research ArticleResearch Article: New Research, Cognition and Behavior

Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex

Brian A. Upton, Gowri Nayak, Ivy Schweinzger, Shane P. D’Souza, Charles V. Vorhees, Michael T. Williams, Brian R. Earl and Richard A. Lang
eNeuro 30 August 2022, 9 (5) ENEURO.0202-22.2022; https://doi.org/10.1523/ENEURO.0202-22.2022
Brian A. Upton
1The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
2Center for Chronobiology, Division of Pediatric Ophthalmology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
3Molecular and Developmental Biology Graduate Program, University of Cincinnati, College of Medicine, Cincinnati, OH 45229
4Medical Scientist Training Program, University of Cincinnati, College of Medicine, Cincinnati, OH 45267
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Gowri Nayak
1The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
2Center for Chronobiology, Division of Pediatric Ophthalmology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
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Ivy Schweinzger
5Department of Communication Sciences and Disorders, University of Cincinnati, College of Allied Health Sciences, Cincinnati, OH 45267
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Shane P. D’Souza
1The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
2Center for Chronobiology, Division of Pediatric Ophthalmology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
3Molecular and Developmental Biology Graduate Program, University of Cincinnati, College of Medicine, Cincinnati, OH 45229
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Charles V. Vorhees
7Division of Pediatric Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
8Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229
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  • ORCID record for Charles V. Vorhees
Michael T. Williams
7Division of Pediatric Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
8Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229
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Brian R. Earl
5Department of Communication Sciences and Disorders, University of Cincinnati, College of Allied Health Sciences, Cincinnati, OH 45267
6Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, College of Medicine, Cincinnati, OH 45267
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Richard A. Lang
1The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
2Center for Chronobiology, Division of Pediatric Ophthalmology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
9Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
10Department of Ophthalmology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0202-22.2022
PubMed 
36041828
Published By 
Society for Neuroscience
History 
  • Received May 20, 2022
  • Revision received June 13, 2022
  • Accepted June 23, 2022
  • Published online August 30, 2022.
Copyright & Usage 
Copyright © 2022 Upton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Brian A. Upton1,2,3,4,
  2. Gowri Nayak1,2,
  3. Ivy Schweinzger5,
  4. Shane P. D’Souza1,2,3,
  5. Charles V. Vorhees7,8,
  6. Michael T. Williams7,8,
  7. Brian R. Earl5,6 and
  8. Richard A. Lang1,2,9,10
  1. 1The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
  2. 2Center for Chronobiology, Division of Pediatric Ophthalmology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
  3. 3Molecular and Developmental Biology Graduate Program, University of Cincinnati, College of Medicine, Cincinnati, OH 45229
  4. 4Medical Scientist Training Program, University of Cincinnati, College of Medicine, Cincinnati, OH 45267
  5. 5Department of Communication Sciences and Disorders, University of Cincinnati, College of Allied Health Sciences, Cincinnati, OH 45267
  6. 6Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, College of Medicine, Cincinnati, OH 45267
  7. 7Division of Pediatric Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
  8. 8Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229
  9. 9Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
  10. 10Department of Ophthalmology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267
  1. Correspondence should be addressed to Richard A. Lang at richard.lang{at}cchmc.org.
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Author contributions

  1. Author contributions: B.A.U. and R.A.L. designed research; B.A.U., G.N., I.S., S.P.D., and B.R.E. performed research; B.A.U., M.T.W., C.V.V., and R.A.L. analyzed data; B.A.U. wrote the paper.

Disclosures

  • The Lang lab has a sponsored research agreement with BIOS Lighting Inc.

  • This work was supported by National Institutes of Health Grants R01EY027077 and R01EY027711 (to R.A.L.) and 5T32GM063483-16 (to University of Cincinnati Medical Scientist Training Program).

Funding

  • HHS | NIH | National Eye Institute (NEI)

    R01EY027077; R01EY027711
  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    5T32GM063483-19

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 30, 2022).

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Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex
Brian A. Upton, Gowri Nayak, Ivy Schweinzger, Shane P. D’Souza, Charles V. Vorhees, Michael T. Williams, Brian R. Earl, Richard A. Lang
eNeuro 30 August 2022, 9 (5) ENEURO.0202-22.2022; DOI: 10.1523/ENEURO.0202-22.2022

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Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex
Brian A. Upton, Gowri Nayak, Ivy Schweinzger, Shane P. D’Souza, Charles V. Vorhees, Michael T. Williams, Brian R. Earl, Richard A. Lang
eNeuro 30 August 2022, 9 (5) ENEURO.0202-22.2022; DOI: 10.1523/ENEURO.0202-22.2022
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Keywords

  • acoustic startle
  • auditory brainstem response
  • encephalopsin
  • light
  • opsin
  • panopsin

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