Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Neuronal Excitability

Spontaneous Cell Cluster Formation in Human iPSC-Derived Neuronal Spheroid Networks Influences Network Activity

Carl-Johan Hörberg, Ulrica Englund Johansson, Fredrik Johansson and David O’Carroll
eNeuro 10 October 2022, 9 (5) ENEURO.0143-22.2022; https://doi.org/10.1523/ENEURO.0143-22.2022
Carl-Johan Hörberg
1Department of Biology, Lund University, 223 62 Lund, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Carl-Johan Hörberg
Ulrica Englund Johansson
2Department of Health and Caring Sciences, Linnaeus University, 391 82 Kalmar, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fredrik Johansson
1Department of Biology, Lund University, 223 62 Lund, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David O’Carroll
1Department of Biology, Lund University, 223 62 Lund, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0143-22.2022
PubMed 
36216508
Published By 
Society for Neuroscience
History 
  • Received March 31, 2022
  • Revision received August 7, 2022
  • Accepted August 12, 2022
  • Published online October 10, 2022.
Copyright & Usage 
Copyright © 2022 Hörberg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Carl-Johan Hörberg1,
  2. Ulrica Englund Johansson2,
  3. Fredrik Johansson1 and
  4. David O’Carroll1
  1. 1Department of Biology, Lund University, 223 62 Lund, Sweden
  2. 2Department of Health and Caring Sciences, Linnaeus University, 391 82 Kalmar, Sweden
  1. Correspondence should be addressed to Carl-Johan Hörberg at carl-johan.hoerberg{at}biol.lu.se.
View Full Text

Author contributions

  1. Author contributions: C.-J.H., U.E.J., F.J., and D.O. designed research; C.-J.H. performed research; C.-J.H. contributed unpublished reagents/analytic tools; C.-J.H. analyzed data; C.-J.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by the Swedish Research Council (Vetenskapsrådet; Grant VR 2018-03452), EUROSTARS/VINNOVA (Grant 11459-3Dbrainscreen), Crown Process Margareta’s Fund for the visually disabled, The Swedish Eye Fund, and The Fund for visually disabled in Southern Sweden.

Funding

  • Vetenskapsrådet (VR)

    VR 2018-03452
  • EC | H2020 | ERA-LEARN | Eurostars (Eureka)

    11459-3DBrainscreen
  • Crown Princess Margareta’s Found for Visually Disabled

  • The Swedish Eye Fun

  • The Fund for visually disabled in Southern Sweden

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 10, 2022).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2026-02-07
to
E.g., 2026-02-07

Article usage: October 2022 to February 2026

AbstractFullPdf
Oct 2022372497254
Nov 202271298153
Dec 20221512647
Total 2022458921454
Jan 20231412736
Feb 2023714537
Mar 2023213029
Apr 2023310321
May 2023511920
Jun 2023512042
Jul 2023912642
Aug 2023612627
Sep 2023411721
Oct 2023310717
Nov 2023712622
Dec 20232012222
Total 2023851468336
Jan 20242713128
Feb 20241212927
Mar 2024614237
Apr 20241210235
May 20241313025
Jun 2024613420
Jul 20241115626
Aug 20241312147
Sep 20242011732
Oct 20241911222
Nov 2024411612
Dec 2024711615
Total 20241501506326
Jan 20251212639
Feb 2025814919
Mar 2025813122
Apr 2025412638
May 2025412619
Jun 2025912917
Jul 20251113427
Aug 20251113522
Sep 20251318926
Oct 20251315330
Nov 20251514721
Dec 2025715376
Total 20251151698356
Jan 20263117243
Feb 20260354
Total 20263120747
Total83958001519
Back to top

In this issue

eneuro: 9 (5)
eNeuro
Vol. 9, Issue 5
September/October 2022
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Spontaneous Cell Cluster Formation in Human iPSC-Derived Neuronal Spheroid Networks Influences Network Activity
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Spontaneous Cell Cluster Formation in Human iPSC-Derived Neuronal Spheroid Networks Influences Network Activity
Carl-Johan Hörberg, Ulrica Englund Johansson, Fredrik Johansson, David O’Carroll
eNeuro 10 October 2022, 9 (5) ENEURO.0143-22.2022; DOI: 10.1523/ENEURO.0143-22.2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Spontaneous Cell Cluster Formation in Human iPSC-Derived Neuronal Spheroid Networks Influences Network Activity
Carl-Johan Hörberg, Ulrica Englund Johansson, Fredrik Johansson, David O’Carroll
eNeuro 10 October 2022, 9 (5) ENEURO.0143-22.2022; DOI: 10.1523/ENEURO.0143-22.2022
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • 3D neuronal culture
  • astrocytes
  • induced pluripotent stem cells
  • microelectrode arrays
  • neuronal networks

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Galanin inhibits histaminergic neurons via galanin receptor 1
  • sAPPα inhibits neurite outgrowth in primary mouse neurons via GABA B Receptor subunit 1a
  • When Familiar Faces Feel Better: A Framework for Social Neurocognitive Aging in a Rat Model
Show more Research Article: New Research

Neuronal Excitability

  • Galanin inhibits histaminergic neurons via galanin receptor 1
  • The neurexin1β histidine-rich domain is involved in excitatory presynaptic organization and short-term plasticity
  • Fast Spiking Interneurons Autonomously Generate Fast Gamma Oscillations in the Medial Entorhinal Cortex with Excitation Strength Tuning ING–PING Transitions
Show more Neuronal Excitability

Subjects

  • Neuronal Excitability
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2026 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.