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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Surround Inhibition Mediates Pain Relief by Low Amplitude Spinal Cord Stimulation: Modeling and Measurement

John E. Gilbert, Nathan Titus, Tianhe Zhang, Rosana Esteller and Warren M. Grill
eNeuro 23 September 2022, 9 (5) ENEURO.0058-22.2022; https://doi.org/10.1523/ENEURO.0058-22.2022
John E. Gilbert
1Department of Biomedical Engineering, Duke University, Durham, NC, 27708
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Nathan Titus
1Department of Biomedical Engineering, Duke University, Durham, NC, 27708
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Tianhe Zhang
2Neuromodulation Research and Advanced Concepts, Boston Scientific Neuromodulation, Valencia, CA, 91355
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Rosana Esteller
2Neuromodulation Research and Advanced Concepts, Boston Scientific Neuromodulation, Valencia, CA, 91355
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Warren M. Grill
1Department of Biomedical Engineering, Duke University, Durham, NC, 27708
3Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708
4Department of Neurobiology, Duke University School of Medicine, Durham, NC, 27708
5Department of Neurosurgery, Duke University School of Medicine, Durham, NC, 27708
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0058-22.2022
PubMed 
36150892
Published By 
Society for Neuroscience
History 
  • Received February 7, 2022
  • Revision received August 31, 2022
  • Accepted September 17, 2022
  • Published online September 23, 2022.
Copyright & Usage 
Copyright © 2022 Gilbert et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. John E. Gilbert1,
  2. Nathan Titus1,
  3. Tianhe Zhang2,
  4. Rosana Esteller2 and
  5. Warren M. Grill1,3,4,5
  1. 1Department of Biomedical Engineering, Duke University, Durham, NC, 27708
  2. 2Neuromodulation Research and Advanced Concepts, Boston Scientific Neuromodulation, Valencia, CA, 91355
  3. 3Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708
  4. 4Department of Neurobiology, Duke University School of Medicine, Durham, NC, 27708
  5. 5Department of Neurosurgery, Duke University School of Medicine, Durham, NC, 27708
  1. Correspondence should be addressed to Warren M. Grill at warren.grill{at}duke.edu.
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Author contributions

  1. Author contributions: J.E.G., N.T., T.Z., R.E., and W.M.G. designed research; J.E.G. and N.T. performed research; J.E.G. and N.T. analyzed data; J.E.G., N.T., T.Z., R.E., and W.M.G. wrote the paper.

Disclosures

  • T.Z. and R.E. are employees of Boston Scientific Corporation. J.E.G., N.T., T.Z., and W.M.G. have received royalty payments from Boston Scientific Corporation for licensed I.P. W.M.G received compensation from Boston Scientific as a member of the Neuromodulation Scientific Advisory Board. T.Z. and R.E. own Boston Scientific stock, and R.E. owns stock in NeuroPace.

  • This work was supported by a grant to Duke University from Boston Scientific Corporation. This work was also supported by the Robert Plonsey Fellowship from the Duke University Department of Biomedical Engineering.

Funding

  • Boston Scientific Corporation (BSC)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 23, 2022).

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Sep 2022180084
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Nov 202251165124
Dec 2022157348
Total 2022409701758
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Apr 2023118926
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May 20241111235
Jun 202489323
Jul 20241011635
Aug 20241210228
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Total 20241411235410
Jan 20251410025
Feb 20251311333
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Apr 20251111938
May 20251012523
Jun 20251712250
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Total 202572713211
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eneuro: 9 (5)
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September/October 2022
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Surround Inhibition Mediates Pain Relief by Low Amplitude Spinal Cord Stimulation: Modeling and Measurement
John E. Gilbert, Nathan Titus, Tianhe Zhang, Rosana Esteller, Warren M. Grill
eNeuro 23 September 2022, 9 (5) ENEURO.0058-22.2022; DOI: 10.1523/ENEURO.0058-22.2022

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Surround Inhibition Mediates Pain Relief by Low Amplitude Spinal Cord Stimulation: Modeling and Measurement
John E. Gilbert, Nathan Titus, Tianhe Zhang, Rosana Esteller, Warren M. Grill
eNeuro 23 September 2022, 9 (5) ENEURO.0058-22.2022; DOI: 10.1523/ENEURO.0058-22.2022
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Keywords

  • computational modeling
  • in vivo recording
  • neuropathic pain
  • spinal cord stimulation

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