Figure 1C | One-way ANOVA with Tukey’s post hoc test | 0.452 | 0.126 | 17βHSD10-cortex | 5 | 1.094 | 0.096 |
| | | 0.949 | 17βHSD10 hippocampus | 5 | 1.084 | 0.060 |
| | | 0.858 | 17βHSD10-cerebellum | 5 | 1.221 | 0.089 |
| One-way ANOVA with Tukey’s post hoc test | 0.420 | <0.001 | COXIV-cortex | 5 | 1.096 | 0.091 |
| | | 0.992 | COXIV-hippocampus | 5 | 1.002 | 0.084 |
| | | 0.098 | COXIV-cerebellum | 5 | 1.153 | 0.059 |
| One-way ANOVA with Tukey’s post hoc test | 0.760 | 0.833 | 17βHSD10/COXIV-cortex | 5 | 1.061 | 0.137 |
| | | 0.454 | 17βHSD10/COXIV-hippocampus | 5 | 1.203 | 0.100 |
| | | 0.311 | 17βHSD10/COXIV-cerebellum | 5 | 1.143 | 0.160 |
Figure 1E | Mixed ANOVA | | 0.849 | cortex-0 min | 6 | 4972.333 | 26.911 |
| Time (main) | <0.001 | 0.049 | cortex-10 min | 6 | 5023.167 | 34.622 |
| Region (main) | 0.583 | 0.610 | cortex-20 min | 6 | 5173.000 | 37.605 |
| interaction | 0.170 | 0.159 | cortex-30 min | 6 | 5297.000 | 50.440 |
| | | 0.584 | hippocampus-0 min | 6 | 4974.333 | 26.911 |
| | | 0.096 | hippocampus-10 min | 6 | 5007.167 | 34.622 |
| | | 0.407 | hippocampus-20 min | 6 | 5127.500 | 37.605 |
| | | 0.059 | hippocampus-30 min | 6 | 5186.333 | 50.440 |
| | | 0.119 | cerebellum-0 min | 6 | 4969.167 | 26.911 |
| | | 0.332 | cerebellum-10 min | 6 | 5069.000 | 34.622 |
| | | 0.552 | cerebellum-20 min | 6 | 5176.500 | 37.605 |
| | | 0.562 | cerebellum-30 min | 6 | 5252.167 | 50.440 |
Figure 2A | One-way ANOVA with Tukey’s post hoc test | <0.001 | 0.042 | control | 7 | 1.191 | 0.316 |
| | | 0.258 | mut-17βHSD10 | 7 | 18.429 | 2.879 |
| | | 0.078 | wt-17βHSD10 | 7 | 18.573 | 3.096 |
Figure 2B | One-way ANOVA with Tukey’s post hoc test | <0.001 | 0.244 | control | 9 | 113.119 | 1.098 |
| | | 0.781 | mut-17βHSD10 | 9 | 115.079 | 1.570 |
| | | 0.018 | wt-17βHSD10 | 9 | 439.268 | 89.354 |
Figure 2D | Mixed linear model with Tukey’s post hoc test | | <0.001 | control | 254 | 685.867 | 17.373 |
| | | <0.001 | mut-17βHSD10 | 244 | 703.992 | 20.494 |
| | | <0.001 | wt-17βHSD10 | 254 | 684.278 | 15.635 |
| Main effect of expression | F(2,743) = 0.308, p = 0.691, ηp2 = 0.133 |
| Main effect of culture replicate | F(2,743) = 0.029, p = 0.971, ηp2 = 0.014 |
| Interaction | F(4,743) = 1.331, p = 0.257, ηp2 = 0.007 |
Figure 2E | Mixed linear model with Tukey’s post hoc test | | <0.001 | control | 255 | 1.761 | 0.021 |
| | | <0.001 | mut-17βHSD10 | 235 | 2.049 | 0.033 |
| | | <0.001 | wt-17βHSD10 | 223 | 2.002 | 0.030 |
| Main effect of expression | F(2,704) = 30.155, p = 0.004, ηp2 = 0.938 |
| Main effect of culture replicate | F(2,704) = 0.211, p = 0.818, ηp2 = 0.095 |
| Interaction | F(4,704) = 1.075, p = 0.368, ηp2 = 0.006 |
Figure 2F | Mixed linear model with Tukey’s post hoc test | <0.001 | 0.001 | control | 253 | 2.929 | 0.058 |
| | | <0.001 | mut-17βHSD10 | 246 | 4.172 | 0.078 |
| | | <0.001 | wt-17βHSD10 | 225 | 3.971 | 0.079 |
| Main effect of expression | F(2,715) = 212.558, p < 0.001, ηp2 = 0.991 |
| Main effect of culture replicate | F(2,715) = 0.449, p = 0.667, ηp2 = 0.182 |
| Interaction | F(4,715) = 0.417, p = 0.797, ηp2 = 0.002 |
Figure 2G | Mixed linear model with Tukey’s post hoc test | 0.009 | <0.001 | control | 255 | 2.677 | 0.095 |
| | | <0.001 | mut-17βHSD10 | 246 | 3.070 | 0.111 |
| | | <0.001 | wt-17βHSD10 | 203 | 3.078 | 0.119 |
| Main effect of expression | F(2,715) = 8.267, p = 0.256, ηp2 = 0.494 |
| Main effect of culture replicate | F(2,715) = 0.254, p = 0.787, ηp2 = 0.112 |
| Interaction | F(4,715) = 2.535, p = 0.0.39, ηp2 = 0.014 |
Figure 3B | One-way ANOVA with Tukey’s post hoc test | 0.124 | | Basal respiration | | | |
| | | 0.196 | control | 11 | 9459.894 | 702.399 |
| | | 0.319 | mut-17βHSD10 | 11 | 9365.145 | 461.574 |
| | | 0.207 | wt-17βHSD10 | 11 | 8227.585 | 634.004 |
| | | 0.525 | wt-17βHSD10-AG18051 | 11 | 10,289.873 | 550.445 |
| One-way ANOVA with Tukey’s post hoc test | <0.001 | | Maximal respiration | | | |
| | | 0.524 | control | 11 | 16,182.764 | 849.316 |
| | | 0.566 | mut-17βHSD10 | 11 | 15,564.403 | 692.724 |
| | | 0.663 | wt-17βHSD10 | 11 | 10,644.094 | 931.124 |
| | | 0.749 | wt-17βHSD10-AG18051 | 11 | 17,685.873 | 740.995 |
| One-way ANOVA with Tukey’s post hoc test | <0.001 | | Spare capacity | | | |
| | | 0.471 | control | 11 | 6722.869 | 287.169 |
| | | 0.854 | mut-17βHSD10 | 11 | 6199.257 | 407.046 |
| | | 0.675 | wt-17βHSD10 | 11 | 2416.509 | 485.998 |
| | | 0.902 | wt-17βHSD10-AG18051 | 11 | 7396.000 | 511.162 |
| One-way ANOVA with Tukey’s post hoc test | <0.001 | | ATP | | | |
| | | 0.205 | control | 11 | 7116.955 | 510.235 |
| | | 0.987 | mut-17βHSD10 | 11 | 6894.442 | 377.057 |
| | | 0.295 | wt-17βHSD10 | 11 | 6103.095 | 494.693 |
| | | 0.398 | wt-17βHSD10-AG18051 | 11 | 7620.969 | 426.466 |
| One-way ANOVA with Tukey’s post hoc test | 0.248 | | Proton leak | | | |
| | | 0.322 | control | 11 | 2342.939 | 218.751 |
| | | 0.047 | mut-17βHSD10 | 11 | 2470.702 | 236.700 |
| | | 0.026 | wt-17βHSD10 | 11 | 2124.490 | 171.068 |
| | | 0.210 | wt-17βHSD10-AG18051 | 11 | 2767.481 | 261.637 |
Figure 3C | One-way ANOVA with Tukey’s post hoc test | <0.001 | | mut-17βHSD10 | | | |
| | | 0.680 | control | 6 | 105.412 | 2.603 |
| | | 0.268 | FCCP | 6 | 99.763 | 3.576 |
| | | 0.868 | OM | 6 | 100.262 | 9.700 |
| | | 0.385 | AA | 6 | 69.928 | 3.920 |
| | | 0.563 | ROT | 6 | 63.441 | 3.079 |
| One-way ANOVA with Tukey’s post hoc test | 0.239 | | mut-17βHSD10-AG18051 | | | |
| | | 0.601 | control | 5 | 96.463 | 7.560 |
| | | 0.576 | FCCP | 5 | 97.961 | 6.000 |
| | | 0.523 | OM | 5 | 86.966 | 7.697 |
| | | 0.046 | AA | 5 | 98.821 | 10.812 |
| | | 0.213 | ROT | 5 | 77.290 | 3.938 |
| One-way ANOVA with Tukey’s post hoc test | <0.001 | | wt-17βHSD10 | | | |
| | | 0.219 | control | 6 | 174.683 | 3.501 |
| | | 0.079 | FCCP | 6 | 197.215 | 7.434 |
| | | 0.435 | OM | 6 | 185.665 | 28.768 |
| | | 0.158 | AA | 6 | 114.067 | 7.088 |
| | | 0.858 | ROT | 6 | 87.097 | 4.562 |
| One-way ANOVA with Tukey’s post hoc test | 0.168 | | wt-17βHSD10-AG18051 | | | |
| | | 0.827 | control | 4 | 99.756 | 10.407 |
| | | 0.745 | FCCP | 5 | 102.113 | 4.069 |
| | | 0.552 | OM | 5 | 92.224 | 6.437 |
| | | 0.126 | AA | 5 | 102.260 | 10.680 |
| | | 0.086 | ROT | 5 | 78.412 | 5.266 |
Figure 3D | One-way ANOVA with Tukey’s post hoc test | <0.001 | 0.205 | control | 11 | 174.205 | 5.353 |
| | | 0.897 | mut-17βHSD10 | 11 | 167.062 | 5.353 |
| | | 0.495 | wt-17βHSD10 | 11 | 129.654 | 5.353 |
| | | 0.451 | wt-17βHSD10-AG18051 | 7 | 166.592 | 6.710 |
Extended Data Fig. 3-1B | Two-tailed unpaired t tests | 0.337 | | Basal respiration Control AG18051 | 11 6 | 9460 10,712 | 702.4 1137 |
| | 0.036 | | Maximal respiration Control AG18051 | 11 6 | 16,183 19,850 | 849.3 1516 |
| | 0.005 | | Spare capacity Control AG18051 | 11 6 | 6723 9138 | 287.2 868.8 |
| | 0.741 | | ATP production Control AG18051 | 11 6 | 7117 7435 | 510.2 875.7 |
| | 0.023 | | Proton leak Control AG18051 | 11 6 | 2343 3372 | 218.8 381.3 |
Figure 4B | One-way ANOVA with Tukey’s post hoc test | 0.005 | | 17βHSD10 | | | |
| | | 0.898 | Control | 6 | 0.925 | 0.133 |
| | | 0.066 | IR | 6 | 1.431 | 0.121 |
| | | 0.176 | IR+glucose | 6 | 0.852 | 0.083 |
| One-way ANOVA with Tukey’s post hoc test | <0.001 | | VDAC1 | | | |
| | | 0.873 | Control | 6 | 0.850 | 0.089 |
| | | 0.592 | IR | 6 | 1.840 | 0.172 |
| | | 0.203 | IR+glucose | 6 | 0.891 | 0.110 |
| One-way ANOVA with Tukey’s post hoc test | 0.442 | | 17βHSD10/COXIV | | | |
| | | 0.753 | Control | 5 | 0.864 | 0.099 |
| | | 0.005 | IR | 5 | 0.766 | 0.098 |
| | | 0.055 | IR+glucose | 5 | 0.693 | 0.076 |
Figure 4C | Mixed ANOVA | | 0.314 | control-control | 12 | 100.000 | 3.410 |
| Group (main) | 0.290 | 0.112 | control-IR | 12 | 82.999 | 4.985 |
| Treatment (main) | <0.001 | 0.716 | mut-17βHSD10-control | 12 | 103.521 | 4.272 |
| interaction | 0.977 | 0.533 | mut-17βHSD10-IR | 12 | 86.108 | 2.443 |
| | | 0.145 | wt-17βHSD10-control | 12 | 101.045 | 3.106 |
| | | 0.271 | wt-17βHSD10-IR | 12 | 85.337 | 5.805 |
Figure 4D | Mixed ANOVA | | 0.026 | control-control | 12 | 2.221 | 0.243 |
| Group (main) | 0.002 | 0.020 | control-IR | 12 | 15.781 | 3.006 |
| Treatment (main) | 0.522 | 0.050 | mut-17βHSD10-control | 12 | 1.563 | 0.212 |
| interaction | <0.001 | 0.189 | mut-17βHSD10-IR | 12 | 15.269 | 3.001 |
| | | 0.500 | wt-17βHSD10-control | 12 | 2.043 | 0.116 |
| | | 0.088 | wt-17βHSD10-IR | 12 | 16.045 | 2.333 |
Figure 5A | Mixed ANOVA | | | | | | |
| Group (main) | <0.001 | 0.244 | control-control | 6 | 127.860 | 9.436 |
| Treatment (main) | <0.001 | 0.901 | control-IR | 6 | 323.533 | 4.313 |
| interaction | <0.001 | 0.582 | control-IR-AG18051 | 6 | 173.563 | 4.331 |
| | | 0.141 | mut-17βHSD10-control | 6 | 140.961 | 9.189 |
| | | 0.114 | mut-17βHSD10-IR | 6 | 283.245 | 7.154 |
| | | 0.031 | mut-17βHSD10-IR-AG18051 | 6 | 215.737 | 22.617 |
| | | 0.655 | wt-17βHSD10-control | 6 | 361.384 | 26.606 |
| | | 0.011 | wt-17βHSD10-IR | 6 | 1026.559 | 133.923 |
| | | 0.070 | wt-17βHSD10-IR-AG18051 | 6 | 196.246 | 18.773 |
Figure 5B | Mixed ANOVA | | 0.475 | control-control | 6 | 96.693 | 6.355 |
| Group (main) | 0.093 | 0.029 | control-IR | 3 | 160.736 | 8.422 |
| Treatment (main) | <0.001 | 0.830 | control-IR-AG18051 | 3 | 112.557 | 21.545 |
| interaction | 0.029 | 0.385 | mut-17βHSD10-control | 6 | 96.662 | 16.852 |
| | | 0.322 | mut-17βHSD10-IR | 3 | 150.052 | 36.172 |
| | | 0.179 | mut-17βHSD10-IR-AG18051 | 3 | 137.171 | 21.279 |
| | | 0.153 | wt-17βHSD10-control | 6 | 85.644 | 9.051 |
| | | 0.776 | wt-17βHSD10-IR | 3 | 240.813 | 12.960 |
| | | 0.673 | wt-17βHSD10-IR-AG18051 | 3 | 133.154 | 18.287 |
Figure 5C | Two-way ANOVA | | | control-control | 7 | 2.879 | 0.393 |
Group (main) | <0.001 | | control-IR | 7 | 8.036 | 0.840 |
Treatment (main) | 0.444 | | control-IR-AG18051 | 7 | 8.943 | 1.399 |
interaction | <0.001 | | mut-17βHSD10-control | 21 | 2.658 | 0.503 |
| | | mut-17βHSD10-IR | 21 | 8.764 | 0.960 |
| | | mut-17βHSD10-IR-AG18051 | 21 | 6.591 | 1.647 |
| | | wt-17βHSD10-control | 12 | 1.875 | 0.369 |
| | | wt-17βHSD10-IR | 12 | 11.429 | 0.834 |
| | | wt-17βHSD10-IR-AG18051 | 12 | 2.905 | 0.495 |
Figure 5E | Mixed linear model with Tukey’s post hoc test | | <0.001 | control-control | 45 | 640.292 | 34.194 |
<0.006 | control-IR | 45 | 254.570 | 15.413 |
0.022 | mut-17βHSD10-control | 45 | 719.772 | 35.778 |
0.039 | mut-17βHSD10-IR | 45 | 647.206 | 35.228 |
0.012 | wt-17βHSD10-control | 45 | 694.020 | 34.624 |
0.051 | wt-17βHSD10-IR | 45 | 903.350 | 39.936 |
Main effect of expression | F(1,243) = 22.702, p = 0.006 |
Main effect of treatment | F(1,243) = 38.381, p = 0.022 |
Interaction | F(2,243) = 96.796, p < 0.001 |
Main effect of culture replicate | F(2,243) = 0.674, p = 0.568 |
Figure 5F | Mixed linear model with Tukey’s post hoc test | | <0.001 | control-control | 45 | 1.420 | 0.025 |
0.331 | control-IR | 45 | 1.394 | 0.017 |
0.941 | mut-17βHSD10-control | 45 | 1.633 | 0.012 |
0.412 | mut-17βHSD10-IR | 45 | 1.542 | 0.024 |
0.126 | wt-17βHSD10-control | 45 | 1.774 | 0.025 |
<0.001 | wt-17βHSD10-IR | 45 | 1.685 | 0.016 |
Main effect of expression | F(1,243) = 14.491, p = 0.015 |
Main effect of treatment | F(1,243) = 15.029, p = 0.060 |
Interaction | F(2,243) = 0.190, p = 0.834 |
Main effect of culture replicate | F(2,243) = 0.399, p = 0.941 |
Figure 5G | Mixed linear model with Tukey’s post hoc test | | 0.018 | control-control | 45 | 1.949 | 0.074 |
| | | 0.308 | control-IR | 45 | 1.563 | 0.065 |
| | | 0.046 | mut-17βHSD10-control | 45 | 4.152 | 0.144 |
| | | 0.003 | mut-17βHSD10-IR | 45 | 2.661 | 0.158 |
| | | 0.005 | wt-17βHSD10-control | 45 | 4.350 | 0.204 |
| | | 0.128 | wt-17βHSD10-IR | 45 | 4.501 | 0.121 |
| Main effect of expression | F(1,243) = 65.562, p = 0.001 |
| Main effect of treatment | F(1,243) = 8.388, p = 0.101 |
| Interaction | F(2,243) = 7.770, p = 0.041 |
| Main effect of culture replicate | F(2,243) = 0.612, p = 0.629 |
Figure 5H | Mixed linear model with Tukey’s post hoc test | | 0.689 | control-control | 45 | 1.352 | 0.036 |
| | | 0.772 | control-IR | 45 | 1.309 | 0.025 |
| | | 0.062 | mut-17βHSD10-control | 45 | 2.530 | 0.077 |
| | | 0.003 | mut-17βHSD10-IR | 45 | 1.684 | 0.081 |
| | | <0.001 | wt-17βHSD10-control | 45 | 2.443 | 0.108 |
| | | 0.158 | wt-17βHSD10-IR | 45 | 2.682 | 0.076 |
| Main effect of expression | F(1,243) = 45.037, p = 0.002 |
| Main effect of treatment | F(1,243) = 6.758, p = 0.121 |
| Interaction | F(2,243) = 22.136, p = 0.007 |
| Main effect of culture replicate | F(2,243) = 0.232, p = 0.805 |
| One-way ANOVA with Tukey’s post hoc test | 0.019 | | 17βHSD10 | | | |
Figure 6B | | | 0.900 | 0 nm | 5 | 0.972 | 0.113 |
| | | 0.650 | 100 nm | 5 | 1.317 | 0.081 |
| | | 0.819 | 1000 nm | 5 | 1.366 | 0.072 |
| One-way ANOVA with Tukey’s post hoc test | 0.809 | | VDAC1 | | | |
| | | <0.001 | 0 nm | 3 | 1.067 | 0.067 |
| | | 0.949 | 100 nm | 3 | 1.029 | 0.141 |
| | | 0.902 | 1000 nm | 3 | 1.155 | 0.182 |
| One-way ANOVA with Tukey’s post hoc test | 0.528 | | 17βHSD10/COXIV | | | |
| | | 0.463 | 0 nm | 5 | 0.944 | 0.067 |
| | | 0.683 | 100 nm | 5 | 0.775 | 0.061 |
| | | 0.202 | 1000 nm | 5 | 0.851 | 0.154 |
Figure 6C | Mixed ANOVA | | 0.304 | control-control | 8 | 109.015 | 4.408 |
| Group (main) | 0.002 | 0.815 | control-Aβ | 8 | 115.155 | 5.896 |
| Treatment (main) | 0.165 | 0.209 | mut-17βHSD10-control | 8 | 112.757 | 5.435 |
| interaction | 0.044 | 0.229 | mut-17βHSD10-Aβ | 8 | 109.097 | 4.470 |
| | | 0.508 | wt-17βHSD10-control | 8 | 104.241 | 6.616 |
| | | 0.034 | wt-17βHSD10-Aβ | 8 | 83.870 | 3.612 |
Figure 6D | Mixed ANOVA | | 0.216 | control-control | 8 | 0.873 | 0.385 |
| Group (main) | 0.005 | 0.003 | control-Aβ | 8 | 3.202 | 0.397 |
| Treatment (main) | <0.001 | 0.395 | mut-17βHSD10-control | 8 | 0.942 | 0.334 |
| interaction | 0.285 | 0.761 | mut-17βHSD10-Aβ | 8 | 3.248 | 0.375 |
| | | 0.698 | wt-17βHSD10-control | 8 | 1.485 | 0.302 |
| | | 0.076 | wt-17βHSD10-Aβ | 8 | 4.815 | 0.379 |
Figure 7A | Mixed ANOVA | | | | | | |
| Group (main) | <0.001 | 0.796 | control-control | 8 | 97.837 | 3.182 |
| Treatment (main) | <0.001 | 0.870 | control-Aβ | 8 | 98.334 | 2.863 |
| interaction | <0.001 | 0.454 | control-Aβ-AG18051 | 8 | 104.191 | 3.936 |
| | | 0.147 | mut-17βHSD10-control | 8 | 96.317 | 2.262 |
| | | 0.827 | mut-17βHSD10-Aβ | 8 | 91.433 | 4.324 |
| | | 0.859 | mut-17βHSD10-Aβ-AG18051 | 8 | 95.197 | 4.067 |
| | | 0.713 | wt-17βHSD10-control | 8 | 374.482 | 11.633 |
| | | 0.444 | wt-17βHSD10-Aβ | 8 | 324.850 | 11.826 |
| | | 0.168 | wt-17βHSD10-Aβ-AG18051 | 8 | 104.093 | 2.924 |
Figure 7B | Mixed ANOVA | | 0.641 | control-control | 8 | 100.000 | 10.408 |
| Group (main) | 0.242 | 0.400 | control-Aβ | 8 | 171.792 | 24.816 |
| Treatment (main) | <0.001 | 0.901 | control-Aβ-AG18051 | 8 | 103.411 | 16.303 |
| interaction | 0.204 | 0.108 | mut-17βHSD10-control | 8 | 106.125 | 10.044 |
| | | 0.150 | mut-17βHSD10-Aβ | 8 | 172.123 | 22.324 |
| | | 0.788 | mut-17βHSD10-Aβ-AG18051 | 8 | 78.465 | 16.038 |
| | | 0.003 | wt-17βHSD10-control | 8 | 114.667 | 13.606 |
| | | 0.296 | wt-17βHSD10-Aβ | 8 | 241.006 | 39.597 |
| | | 0.111 | wt-17βHSD10-Aβ-AG18051 | 8 | 81.276 | 7.345 |
Figure 7C | Two-way ANOVA | | | control-control | 8 | 0.873 | 0.385 |
| | | | control-Aβ | 8 | 4.024 | 0.182 |
| Group (main) | 0.017 | | control-Aβ-AG18051 | 8 | 3.558 | 0.589 |
| Treatment (main) | <0.001 | | mut-17βHSD10-control | 8 | 0.942 | 0.333 |
| interaction | 0.521 | | mut-17βHSD10-Aβ | 8 | 3.274 | 0.375 |
| | | | mut-17βHSD10-Aβ-AG18051 | 8 | 2.590 | 0.413 |
| | | wt-17βHSD10-control | 8 | 1.784 | 0.266 |
| | | wt-17βHSD10-Aβ | 8 | 4.606 | 0.447 |
| | | wt-17βHSD10-Aβ-AG18051 | 8 | 3.284 | 0.474 |
Figure 7E | Mixed linear model with Tukey’s post hoc test | | 0.048 | control-control | 120 | 738.426 | 26.021 |
| | | 0.006 | control-Aβ | 120 | 559.937 | 22.975 |
| | | <0.001 | mut-17βHSD10-control | 120 | 796.907 | 32.100 |
| | | <0.001 | mut-17βHSD10-Aβ | 120 | 536.263 | 25.395 |
| | | <0.001 | wt-17βHSD10-control | 120 | 743.826 | 22.845 |
| | | 0.231 | wt-17βHSD10-Aβ | 120 | 476.186 | 15.730 |
| Main effect of expression | F(2,702) = 0.500, p = 0.640 |
| Main effect of treatment | F(1,702) = 30.749, p = 0.031 |
| Interaction | F(2,702) = 0.668, p = 0.562 |
| Main effect of culture replicate | F(2,702) = 1.113, p = 0.454 |
Figure 7F | Mixed linear model with Tukey’s post hoc test | | 0.006 | control-control | 120 | 2.004 | 0.024 |
| | | <0.001 | control-Aβ | 120 | 1.804 | 0.034 |
| | | 0.007 | mut-17βHSD10-control | 120 | 2.439 | 0.036 |
| | | <0.001 | mut-17βHSD10-Aβ | 120 | 1.933 | 0.040 |
| | | <0.001 | wt-17βHSD10-control | 120 | 2.324 | 0.034 |
| | | <0.001 | wt-17βHSD10-Aβ | 120 | 1.681 | 0.013 |
| Main effect of expression | F(2,702) = 3.629, p = 0.034 |
| Main effect of treatment | F(1,702) = 78.927, p = 0.012 |
| Interaction | F(2,702) = 21.179, p = 0.007 |
| Main effect of culture replicate | F(2,702) = 2.323, p = 0.226 |
Figure 7G | Mixed linear model | | 0.011 | control-control | 120 | 3.194 | 0.084 |
| | <0.001 | 0.399 | control-Aβ | 120 | 3.127 | 0.081 |
| | <0.001 | <0.001 | mut-17βHSD10-control | 120 | 4.382 | 0.117 |
| | <0.001 | 0.066 | mut-17βHSD10-Aβ | 120 | 4.463 | 0.111 |
| | | <0.001 | wt-17βHSD10-control | 120 | 4.080 | 0.110 |
| | | <0.001 | wt-17βHSD10-Aβ | 120 | 2.753 | 0.150 |
| Main effect of expression | F(2,702) = 5.364, p = 0.074 |
| Main effect of treatment | F(1,702) = 22.354, p = 0.042 |
| Interaction | F(2,702) = 12.575, p = 0.019 |
| Main effect of culture replicate | F(2,702) = 0.526, p = 0.640 |
Figure 7H | Mixed linear model | | <0.001 | control-control | 120 | 3.311 | 0.127 |
| | | <0.001 | control-Aβ | 120 | 3.148 | 0.110 |
| | | <0.001 | mut-17βHSD10-control | 120 | 3.709 | 0.201 |
| | | <0.001 | mut-17βHSD10-Aβ | 120 | 4.070 | 0.187 |
| | | <0.001 | wt-17βHSD10-control | 120 | 4.130 | 0.189 |
| | | <0.001 | wt-17βHSD10-Aβ | 120 | 3.111 | 0.189 |
| Main effect of expression | F(2,702) = 2.047, p = 0.244 |
| Main effect of treatment | F(1,702) = 207.886, p = 0.005 |
| Interaction | F(2,702) = 13.591, p = 0.016 |
| Main effect of culture replicate | F(2,702) = 3.066, p = 0.216 |