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Research ArticleResearch Article: Negative Results, Cognition and Behavior

Lack of Causal Roles of Cannabinoid and Dopamine Neurotransmitter Systems in Orbitofrontal and Piriform Cortex in Fentanyl Relapse in Rats

Sarah M. Claypool, Sana Behdin, Sarah V. Applebey, Javier Orihuel, Zilu Ma and David J. Reiner
eNeuro 29 June 2022, 9 (4) ENEURO.0496-21.2022; DOI: https://doi.org/10.1523/ENEURO.0496-21.2022
Sarah M. Claypool
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
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Sana Behdin
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
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Sarah V. Applebey
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
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Javier Orihuel
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
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Zilu Ma
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
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David J. Reiner
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0496-21.2022
PubMed 
35768212
Published By 
Society for Neuroscience
History 
  • Received November 28, 2021
  • Revision received June 8, 2022
  • Accepted June 18, 2022
  • Published online June 29, 2022.
Copyright & Usage 
Copyright © 2022 Claypool et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sarah M. Claypool,
  2. Sana Behdin,
  3. Sarah V. Applebey,
  4. Javier Orihuel,
  5. Zilu Ma and
  6. David J. Reiner
  1. Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
  1. Correspondence should be addressed to David J. Reiner at david.reiner{at}nih.gov.
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Author contributions

  1. Author contributions: D.J.R. designed research; S.M.C., S.B., S.V.A., J.O., Z.M., and D.J.R. performed research; S.M.C., S.B., S.V.A., J.O., Z.M., and D.J.R. analyzed data; S.M.C., S.B., and D.J.R. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by grants 1FI2GM128603 and K99DA053211-01A1 (to D.J.R.) and funds to the Neurobiology of Relapse Section (PI: Yavin Shaham) and Neuroimaging Research Branch (PI: Yihong Yang). Support for a student internship (S.B.) is provided in part by the National Institutes of Health-National Institute of General Medical Sciences Building Infrastructure Leading to Diversity (BUILD) Initiative Grant 5TL4GM118989 and the NIDA EDUCATE University of Maryland, Baltimore County Research Training Program Grant 3R25DA051338.

Funding

  • NIH

    1FI2GM128603; 5TL4GM118989; 3R25DA051338; K99DA053211-01A1

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Lack of Causal Roles of Cannabinoid and Dopamine Neurotransmitter Systems in Orbitofrontal and Piriform Cortex in Fentanyl Relapse in Rats
Sarah M. Claypool, Sana Behdin, Sarah V. Applebey, Javier Orihuel, Zilu Ma, David J. Reiner
eNeuro 29 June 2022, 9 (4) ENEURO.0496-21.2022; DOI: 10.1523/ENEURO.0496-21.2022

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Lack of Causal Roles of Cannabinoid and Dopamine Neurotransmitter Systems in Orbitofrontal and Piriform Cortex in Fentanyl Relapse in Rats
Sarah M. Claypool, Sana Behdin, Sarah V. Applebey, Javier Orihuel, Zilu Ma, David J. Reiner
eNeuro 29 June 2022, 9 (4) ENEURO.0496-21.2022; DOI: 10.1523/ENEURO.0496-21.2022
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Keywords

  • addiction
  • cannabinoids
  • dopamine
  • opioid
  • relapse
  • self-administration

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