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Research ArticleResearch Article: Confirmation, Disorders of the Nervous System

Confirmation of Decreased Rates of Cerebral Protein Synthesis In Vivo in a Mouse Model of Tuberous Sclerosis Complex

Rachel Michelle Saré, Anita Torossian, Inna Loutaev and Carolyn Beebe Smith
eNeuro 18 July 2022, 9 (4) ENEURO.0480-21.2022; DOI: https://doi.org/10.1523/ENEURO.0480-21.2022
Rachel Michelle Saré
Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814
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Anita Torossian
Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814
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Inna Loutaev
Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814
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Carolyn Beebe Smith
Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0480-21.2022
PubMed 
35851298
Published By 
Society for Neuroscience
History 
  • Received November 15, 2021
  • Revision received April 29, 2022
  • Accepted May 23, 2022
  • Published online July 18, 2022.
Copyright & Usage 
Copyright © 2022 Saré et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Rachel Michelle Saré,
  2. Anita Torossian,
  3. Inna Loutaev and
  4. Carolyn Beebe Smith
  1. Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814
  1. Correspondence should be addressed to Carolyn Beebe Smith at beebe{at}mail.nih.gov.
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Author contributions

  1. Author contributions: R.M.S. and C.B.S. designed research; A.T. and I.L. performed research; R.M.S., A.T., and C.B.S. analyzed data; R.M.S. and C.B.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Intramural Research Program of the National Institute of Mental Health Grant ZIA MH000889. R.M.S. was also supported by a postdoctoral fellowship from Fragile X Syndrome Research Foundation.

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    ZIA MH000889
  • FRAXA Research Foundation (FRF)

    Postdoctoral Felowship

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eneuro: 9 (4)
eNeuro
Vol. 9, Issue 4
July/August 2022
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Confirmation of Decreased Rates of Cerebral Protein Synthesis In Vivo in a Mouse Model of Tuberous Sclerosis Complex
Rachel Michelle Saré, Anita Torossian, Inna Loutaev, Carolyn Beebe Smith
eNeuro 18 July 2022, 9 (4) ENEURO.0480-21.2022; DOI: 10.1523/ENEURO.0480-21.2022

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Confirmation of Decreased Rates of Cerebral Protein Synthesis In Vivo in a Mouse Model of Tuberous Sclerosis Complex
Rachel Michelle Saré, Anita Torossian, Inna Loutaev, Carolyn Beebe Smith
eNeuro 18 July 2022, 9 (4) ENEURO.0480-21.2022; DOI: 10.1523/ENEURO.0480-21.2022
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    • Abstract
    • Significance Statement
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Keywords

  • mTOR
  • protein synthesis
  • tuberous sclerosis

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