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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Multiscale Computer Modeling of Spreading Depolarization in Brain Slices

Craig Kelley, Adam J. H. Newton, Sabina Hrabetova, Robert A. McDougal and William W Lytton
eNeuro 4 August 2022, 9 (4) ENEURO.0082-22.2022; DOI: https://doi.org/10.1523/ENEURO.0082-22.2022
Craig Kelley
1Program in Biomedical Engineering, SUNY Downstate Health Sciences University & NYU Tandon School of Engineering, Brooklyn, NY, 11203
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Adam J. H. Newton
2Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
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Sabina Hrabetova
3Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
4Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
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Robert A. McDougal
5Department of Biostatistics, Yale University, New Haven, Connecticut 06513
6Yale Center for Medical Informatics, Yale University, New Haven, Connecticut 06513
7Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06513
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William W Lytton
2Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
4Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
8Department of Neurology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
9Department of Neurology, Kings County Hospital Center, Brooklyn, New York 11203
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0082-22.2022
PubMed 
35927026
Published By 
Society for Neuroscience
History 
  • Received February 21, 2022
  • Revision received June 28, 2022
  • Accepted July 11, 2022
  • Published online August 4, 2022.
Copyright & Usage 
Copyright © 2022 Kelley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Craig Kelley1,
  2. Adam J. H. Newton2,
  3. Sabina Hrabetova3,4,
  4. Robert A. McDougal5,6,7 and
  5. William W Lytton2,4,8,9
  1. 1Program in Biomedical Engineering, SUNY Downstate Health Sciences University & NYU Tandon School of Engineering, Brooklyn, NY, 11203
  2. 2Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
  3. 3Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
  4. 4Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
  5. 5Department of Biostatistics, Yale University, New Haven, Connecticut 06513
  6. 6Yale Center for Medical Informatics, Yale University, New Haven, Connecticut 06513
  7. 7Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06513
  8. 8Department of Neurology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203
  9. 9Department of Neurology, Kings County Hospital Center, Brooklyn, New York 11203
  1. Correspondence should be addressed to Craig Kelley at craig.kelley{at}downstate.edu.
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Author contributions

  1. Author contributions: C.K., A.J.H.N., S.H., R.A.M., and W.W.L. designed research; C.K. and A.J.H.N. performed research; C.K. analyzed data; C.K., A.J.H.N., S.H., R.A.M., and W.W.L. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was funded by National Institutes of Health/National Institute of Mental Health Grant R01-MH-086638 and National Science Foundation Grant Internet2 E-CAS 1904444. We thank Drs. Rena Orman, Mark Stewart, Richard Kollmar, and John Kubie (SUNY Downstate Health Sciences University) for useful discussions on this topic. We also thank Dr. Michael Hines (Yale University) for support with the NEURON simulator.

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01MH086638
  • National Science Foundation (NSF)

    Grant Internet2E-CAS 1904444.

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  • previous version (August 04, 2022).

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eneuro: 9 (4)
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July/August 2022
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Multiscale Computer Modeling of Spreading Depolarization in Brain Slices
Craig Kelley, Adam J. H. Newton, Sabina Hrabetova, Robert A. McDougal, William W Lytton
eNeuro 4 August 2022, 9 (4) ENEURO.0082-22.2022; DOI: 10.1523/ENEURO.0082-22.2022

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Multiscale Computer Modeling of Spreading Depolarization in Brain Slices
Craig Kelley, Adam J. H. Newton, Sabina Hrabetova, Robert A. McDougal, William W Lytton
eNeuro 4 August 2022, 9 (4) ENEURO.0082-22.2022; DOI: 10.1523/ENEURO.0082-22.2022
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Keywords

  • extracellular space
  • hypoxia
  • NEURON
  • reaction-diffusion
  • spreading depolarization
  • spreading depression

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