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Research ArticleResearch Article: Negative Results, Disorders of the Nervous System

14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer’s Disease Mouse Models

Mary Gannon, Bing Wang, Sara Anne Stringfellow, Stephan Quintin, Itzel Mendoza, Thanushri Srikantha, A. Claire Roberts, Takashi Saito, Takaomi C. Saido, Erik D. Roberson and Talene A. Yacoubian
eNeuro 13 June 2022, 9 (3) ENEURO.0368-21.2022; https://doi.org/10.1523/ENEURO.0368-21.2022
Mary Gannon
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
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Bing Wang
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
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Sara Anne Stringfellow
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
2University of South Alabama College of Medicine, Mobile, AL 36688
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Stephan Quintin
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
3Medical Scientist Training Program, University of Florida, Gainesville, FL 32611
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Itzel Mendoza
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
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Thanushri Srikantha
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
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A. Claire Roberts
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
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Takashi Saito
4RIKEN Center for Brain Science, Saitama 351-0198, Japan
5Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduates School of Medical Sciences, Nagaya 467-8601, Japan
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Takaomi C. Saido
4RIKEN Center for Brain Science, Saitama 351-0198, Japan
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Erik D. Roberson
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
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Talene A. Yacoubian
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0368-21.2022
PubMed 
35697511
Published By 
Society for Neuroscience
History 
  • Received August 31, 2021
  • Revision received May 27, 2022
  • Accepted June 1, 2022
  • Published online June 13, 2022.
Copyright & Usage 
Copyright © 2022 Gannon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Mary Gannon1,
  2. Bing Wang1,
  3. Sara Anne Stringfellow1,2,
  4. Stephan Quintin1,3,
  5. Itzel Mendoza1,
  6. Thanushri Srikantha1,
  7. A. Claire Roberts1,
  8. Takashi Saito4,5,
  9. Takaomi C. Saido4,
  10. Erik D. Roberson1 and
  11. Talene A. Yacoubian1
  1. 1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294
  2. 2University of South Alabama College of Medicine, Mobile, AL 36688
  3. 3Medical Scientist Training Program, University of Florida, Gainesville, FL 32611
  4. 4RIKEN Center for Brain Science, Saitama 351-0198, Japan
  5. 5Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduates School of Medical Sciences, Nagaya 467-8601, Japan
  1. Correspondence should be addressed to Talene A. Yacoubian at tyacoubian{at}uabmc.edu.
  • B. Wang’s present address: AAVnergene, Bethesda, MD 20852.

View Full Text

Author contributions

  1. Author contributions: M.G., E.D.R., and T.A.Y. designed research; M.G., B.W., S.A.S., S.Q., I.M., T.Sr., and A.C.R. performed research; T.S.a, T.C.S., and E.D.R. contributed unpublished reagents/analytic tools; M.G., B.W., S.A.S., S.Q., I.M., T.Sr., A.C.R., and T.A.Y. analyzed data; M.G. and T.A.Y. wrote the paper.

  • B. Wang’s present address: AAVnergene, Bethesda, MD 20852.

Disclosures

  • T.A.Y. has a United States Patent #7,919,262 on the use of 14-3-3s in neurodegeneration. All other authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants R01 NS088533 and R01 NS112203 (to T.A.Y.), the Alzheimer’s of Central Alabama (T.A.Y.), and the University of Alabama at Birmingham School of Medicine AMC21 Multi-R01 Pilot Grant (to T.A.Y.).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS088533; NS112203
  • Alzheimer’s of Central Alabama

  • University of Alabama at Birmingham School of Medicine

    AMC21 Multi-R01 Pilot Grant

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 13, 2022).

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Jun 2022413207195
Jul 202243301114
Aug 20222416358
Sep 20221611956
Oct 20223213544
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May 2024109415
Jun 2024410917
Jul 2024211327
Aug 202469025
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Total 2024581159228
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Apr 2025210118
May 202519419
Jun 20253311
Total 20251752387
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14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer’s Disease Mouse Models
Mary Gannon, Bing Wang, Sara Anne Stringfellow, Stephan Quintin, Itzel Mendoza, Thanushri Srikantha, A. Claire Roberts, Takashi Saito, Takaomi C. Saido, Erik D. Roberson, Talene A. Yacoubian
eNeuro 13 June 2022, 9 (3) ENEURO.0368-21.2022; DOI: 10.1523/ENEURO.0368-21.2022

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14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer’s Disease Mouse Models
Mary Gannon, Bing Wang, Sara Anne Stringfellow, Stephan Quintin, Itzel Mendoza, Thanushri Srikantha, A. Claire Roberts, Takashi Saito, Takaomi C. Saido, Erik D. Roberson, Talene A. Yacoubian
eNeuro 13 June 2022, 9 (3) ENEURO.0368-21.2022; DOI: 10.1523/ENEURO.0368-21.2022
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Keywords

  • β-amyloid
  • 14-3-3
  • Alzheimer’s disease
  • Cortex
  • hippocampus
  • mouse model

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