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Research ArticleResearch Article: New Research, Cognition and Behavior

Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation

L. Nava-Gómez, I. Calero-Vargas, F. Higinio-Rodríguez, B. Vázquez-Prieto, R. Olivares-Moreno, J. Ortiz-Retana, P. Aranda, N. Hernández-Chan, G. Rojas-Piloni, S. Alcauter and M. López-Hidalgo
eNeuro 18 May 2022, 9 (3) ENEURO.0176-22.2022; DOI: https://doi.org/10.1523/ENEURO.0176-22.2022
L. Nava-Gómez
1Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México, Querétaro 76230, México
2Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro 76126, México
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I. Calero-Vargas
1Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México, Querétaro 76230, México
3Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México
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F. Higinio-Rodríguez
1Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México, Querétaro 76230, México
3Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México
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B. Vázquez-Prieto
1Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México, Querétaro 76230, México
3Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México
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R. Olivares-Moreno
3Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México
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J. Ortiz-Retana
3Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México
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P. Aranda
4Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro 76230, México
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N. Hernández-Chan
5Facultad de Ingeniería, Universidad Autónoma de Querétaro, Querétaro 76010, México
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G. Rojas-Piloni
3Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México
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S. Alcauter
3Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México
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M. López-Hidalgo
1Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México, Querétaro 76230, México
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0176-22.2022
Published By 
Society for Neuroscience
History 
  • Received May 5, 2022
  • Revision received May 9, 2022
  • Accepted May 13, 2022
  • Published online May 18, 2022.
Copyright & Usage 
Copyright © 2022 Nava-Gómez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. L. Nava-Gómez1,2,*,
  2. I. Calero-Vargas1,3,*,
  3. F. Higinio-Rodríguez1,3,
  4. B. Vázquez-Prieto1,3,
  5. R. Olivares-Moreno3,
  6. J. Ortiz-Retana3,
  7. P. Aranda4,
  8. N. Hernández-Chan5,
  9. G. Rojas-Piloni3,
  10. S. Alcauter3 and
  11. M. López-Hidalgo1
  1. 1Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México, Querétaro 76230, México
  2. 2Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro 76126, México
  3. 3Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México
  4. 4Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro 76230, México
  5. 5Facultad de Ingeniería, Universidad Autónoma de Querétaro, Querétaro 76010, México
  1. Correspondence should be addressed to M. López-Hidalgo at lopezhidalgo{at}unam.mx.
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Author contributions

  1. Author contributions: M.L.-H. designed research; L.N.-G., I.C.-V., F.H.-R., B.V.-P., P.A., and N.H.-C. performed research; J.O.-R., G.R.-P., S.A., and M.L.-H. contributed unpublished reagents/analytic tools; L.N.-G., I.C.-V., F.H.-R., B.V.-P., R.O.-M., G.R.-P., S.A., and M.L.-H. analyzed data; L.N.-G., G.R.-P., S.A., and M.L.-H. wrote the paper.

  2. ↵* L.N.-G. and I.C.-V. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by grants from Consejo Nacional de Ciencia y Tecnologia (CONACyT) Ciencia de Frontera 171874 (to M.L.H.), CONACyT Problemas Nacionales 2132 (to N.H.C.), PAPIIT-DGAPA IA208120 (to M.L.H.), PAPIIT-DGAPA IA208022 (to M.L.H.), CONACYT Ciencia Básica A1-S-8686 (to G.R.-P.), and UNAM-DGAPA PAPIIT IN201121 (to G.R.-P.). L.N.-G. and P.A. are doctoral students from the Programa de Doctorado en Biomedicina, from Universidad Autónoma de Querétaro, and received CONACyT Fellowships 472970 and 815419. I.C.-V. is a doctoral student from the Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM), and received the CONACyT Fellowship 786125. F.H.-R. and B.V.-P. are master students from the Programa de Maestría en Ciencias (Neurobiología) from UNAM and received CONACyT Fellowships 778405 and 778596.

Funding

  • Consejo Nacional de Ciencia y Tecnología (CONACYT)

    472970; 815419); 786125; 778405; 778596; A1-S-8686; 2132; 171874
  • UNAM | Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (DGAPA)

    IN201121; IA208120; IA208022

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  • previous version (May 18, 2022).
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Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation
L. Nava-Gómez, I. Calero-Vargas, F. Higinio-Rodríguez, B. Vázquez-Prieto, R. Olivares-Moreno, J. Ortiz-Retana, P. Aranda, N. Hernández-Chan, G. Rojas-Piloni, S. Alcauter, M. López-Hidalgo
eNeuro 18 May 2022, 9 (3) ENEURO.0176-22.2022; DOI: 10.1523/ENEURO.0176-22.2022

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Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation
L. Nava-Gómez, I. Calero-Vargas, F. Higinio-Rodríguez, B. Vázquez-Prieto, R. Olivares-Moreno, J. Ortiz-Retana, P. Aranda, N. Hernández-Chan, G. Rojas-Piloni, S. Alcauter, M. López-Hidalgo
eNeuro 18 May 2022, 9 (3) ENEURO.0176-22.2022; DOI: 10.1523/ENEURO.0176-22.2022
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Keywords

  • aging
  • cognitive flexibility
  • D-serine
  • fMRI
  • functional brain connectivity

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