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Research ArticleResearch Article: New Research, Integrative Systems

Histochemical Characterization of the Dorsal Raphe-Periaqueductal Grey Dopamine Transporter Neurons Projecting to the Extended Amygdala

Qin Zhao, Tetsufumi Ito, Chika Soko, Yoshie Hori, Takafumi Furuyama, Hiroyuki Hioki, Kohtarou Konno, Miwako Yamasaki, Masahiko Watanabe, Satoshi Ohtsuka, Munenori Ono, Nobuo Kato and Ryo Yamamoto
eNeuro 17 May 2022, 9 (3) ENEURO.0121-22.2022; https://doi.org/10.1523/ENEURO.0121-22.2022
Qin Zhao
1Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
6Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Tetsufumi Ito
2Systems Function and Morphology Laboratory, Graduate School of Innovative Life Science, University of Toyama, Toyama, Toyama 930-0194, Japan
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  • ORCID record for Tetsufumi Ito
Chika Soko
2Systems Function and Morphology Laboratory, Graduate School of Innovative Life Science, University of Toyama, Toyama, Toyama 930-0194, Japan
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Yoshie Hori
1Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
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Takafumi Furuyama
1Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
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  • ORCID record for Takafumi Furuyama
Hiroyuki Hioki
3Department of Neuroanatomy, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan
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Kohtarou Konno
4Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan
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Miwako Yamasaki
4Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan
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Masahiko Watanabe
4Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan
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  • ORCID record for Masahiko Watanabe
Satoshi Ohtsuka
5Laboratory for Experimental Animals, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602-8566, Japan
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Munenori Ono
1Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
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Nobuo Kato
1Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
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Ryo Yamamoto
1Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0121-22.2022
PubMed 
35580986
Published By 
Society for Neuroscience
History 
  • Received March 22, 2022
  • Revision received April 20, 2022
  • Accepted May 3, 2022
  • Published online May 17, 2022.
Copyright & Usage 
Copyright © 2022 Zhao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Qin Zhao1,6,*,
  2. Tetsufumi Ito2,*,
  3. Chika Soko2,
  4. Yoshie Hori1,
  5. Takafumi Furuyama1,
  6. Hiroyuki Hioki3,
  7. Kohtarou Konno4,
  8. Miwako Yamasaki4,
  9. Masahiko Watanabe4,
  10. Satoshi Ohtsuka5,
  11. Munenori Ono1,
  12. Nobuo Kato1 and
  13. Ryo Yamamoto1
  1. 1Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
  2. 2Systems Function and Morphology Laboratory, Graduate School of Innovative Life Science, University of Toyama, Toyama, Toyama 930-0194, Japan
  3. 3Department of Neuroanatomy, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan
  4. 4Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan
  5. 5Laboratory for Experimental Animals, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602-8566, Japan
  6. 6Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  1. Correspondence should be addressed to Ryo Yamamoto at ryamamot{at}kanazawa-med.ac.jp.
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Author contributions

  1. Author contributions: Q.Z., T.I., N.K., and R.Y. designed research; Q.Z., T.I., C.S., Y.H., T.F., H.H., K.K., M.Y., M.W., S.O., M.O., and R.Y. performed research; K.K., M.Y., and M.W. contributed unpublished reagents/analytic tools; Q.Z., T.F., M.O., and R.Y. analyzed data; Q.Z., T.I., N.K., and R.Y. wrote the paper.

  2. ↵* Q.Z. and T.I. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported partly by KAKENHI Grants JP20K21664 and JP19H04212 (to T.I.), JP22K09663 (to C.S.), JP19K24241 and JP20K09209 (to Y.H.), JP19K16192 and JP22K15795 (to T.F.), JP21H02592 (to H.H.), JP21K0674601 (to K.K.), JP20H0341001 (to M.Y.), JP21H0258901 (to M.W.), JP19K06459 (to S.O.), JP19K09918 (to M.O.), and 17H02223 (to N.K.), JP18KK0468 and JP21K07489 (to R.Y.), by JST FOREST Program JPMJFR2151 to (T.I.), and by research grants from Nakatomi Foundation and Takeda Science Foundation (R.Y.), Toyama Dai-ichi Bank Scholarship Foundation (T.I.), and Tamura Science and Technology Foundation, Toyama Prefecture Human Resources Development Foundation, and The University President's Discretionary Expenses (to C.S.).

Funding

  • MEXT | Japan Society for the Promotion of Science (JSPS)

    JP20K21664; JP19H04212; JP19K24241; JP20K09209; JP19K16192; JP21H02592; JP21K0674601; JP20H0341001; JP21H0258901; JP19K06459; JP19K09918; 17H02223; JP18KK0468; JP21K07489; 22K09663; 22K15795
  • Nakatomi Foundation

  • Takeda Science Foundation (公益財団法人 武田科学振興財団)

  • Toyama Dai-ichi Bank Scholarship Foundation

  • Tamura Science and Technology Foundation

  • Toyama Prefecture Human Resources Development Foundation

  • The University President’ Discretionary Expenses

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 17, 2022).

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AbstractFullPdf
May 202234834128
Jun 2022157426202
Jul 20223928372
Aug 20222521446
Sep 20221312928
Oct 20221112834
Nov 20221411143
Dec 202228521
Total 20226091410574
Jan 20231210829
Feb 2023612937
Mar 2023710425
Apr 202329313
May 2023610221
Jun 2023312520
Jul 2023711922
Aug 2023912136
Sep 2023718229
Oct 2023428820
Nov 2023650918
Dec 20231011728
Total 2023791997298
Jan 20241812326
Feb 20241111525
Mar 2024312431
Apr 20241423333
May 20241011044
Jun 2024611635
Jul 2024514237
Aug 202499922
Sep 20242210635
Oct 2024413237
Nov 2024712627
Dec 2024512126
Total 20241141547378
Jan 20251115138
Feb 2025514128
Mar 2025615337
Apr 2025812534
May 2025714447
Jun 2025814431
Jul 20251316549
Aug 20251215623
Sep 20251119541
Oct 20251017534
Nov 20252318034
Dec 20251615456
Total 20251301883452
Jan 2026912432
Total 2026912432
Total94169611734
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Histochemical Characterization of the Dorsal Raphe-Periaqueductal Grey Dopamine Transporter Neurons Projecting to the Extended Amygdala
Qin Zhao, Tetsufumi Ito, Chika Soko, Yoshie Hori, Takafumi Furuyama, Hiroyuki Hioki, Kohtarou Konno, Miwako Yamasaki, Masahiko Watanabe, Satoshi Ohtsuka, Munenori Ono, Nobuo Kato, Ryo Yamamoto
eNeuro 17 May 2022, 9 (3) ENEURO.0121-22.2022; DOI: 10.1523/ENEURO.0121-22.2022

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Histochemical Characterization of the Dorsal Raphe-Periaqueductal Grey Dopamine Transporter Neurons Projecting to the Extended Amygdala
Qin Zhao, Tetsufumi Ito, Chika Soko, Yoshie Hori, Takafumi Furuyama, Hiroyuki Hioki, Kohtarou Konno, Miwako Yamasaki, Masahiko Watanabe, Satoshi Ohtsuka, Munenori Ono, Nobuo Kato, Ryo Yamamoto
eNeuro 17 May 2022, 9 (3) ENEURO.0121-22.2022; DOI: 10.1523/ENEURO.0121-22.2022
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Keywords

  • amygdala
  • bed nucleus of the stria terminalis
  • dopamine
  • dopamine transporter
  • dorsal raphe
  • vasoactive intestinal peptide

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