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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in the Scn1a Haploinsufficiency Mouse Model of Dravet Syndrome

Jessica Hotard Chancey and MacKenzie Allen Howard
eNeuro 6 May 2022, 9 (3) ENEURO.0080-22.2022; DOI: https://doi.org/10.1523/ENEURO.0080-22.2022
Jessica Hotard Chancey
1Department of Neurology, Dell Medical School, Austin 78712, TX
2Department of Neuroscience and Center for Learning and Memory, University of Texas at Austin, Austin 78712, TX
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MacKenzie Allen Howard
1Department of Neurology, Dell Medical School, Austin 78712, TX
2Department of Neuroscience and Center for Learning and Memory, University of Texas at Austin, Austin 78712, TX
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0080-22.2022
PubMed 
35523580
Published By 
Society for Neuroscience
History 
  • Received February 21, 2022
  • Revision received March 29, 2022
  • Accepted April 27, 2022
  • Published online May 6, 2022.
Copyright & Usage 
Copyright © 2022 Chancey and Howard This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jessica Hotard Chancey1,2 and
  2. MacKenzie Allen Howard1,2
  1. 1Department of Neurology, Dell Medical School, Austin 78712, TX
  2. 2Department of Neuroscience and Center for Learning and Memory, University of Texas at Austin, Austin 78712, TX
  1. Correspondence should be addressed to MacKenzie Allen Howard at mackenziehoward{at}austin.utexas.edu.
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Author contributions

  1. Author contributions: J.H.C. and M.A.H. designed research; J.H.C. performed research; J.H.C. and M.A.H. analyzed data; J.H.C. and M.A.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Dravet Syndrome Foundation (postdoctoral fellowship to J.H.C.), postdoctoral fellowship to J.H.C. and a Young Investigator Award to M.A.H. from the American Epilepsy Society, the National Institutes of Health/National Institute of Neurological Disorders and Stroke Grant R01 NS112500-01, and startup funds from Dell Medical School at the University of Texas at Austin.

Funding

  • NIH/NINDS

    R01 NS112500-01
  • Dravet Syndrome Foundation (DSF)

    Postdoctoral Fellowship
  • American Epilepsy Society (AES)

    Young Investigator Award; Postdoctoral Fellowship

Other Version

  • previous version (May 06, 2022).
  • You are viewing the most recent version of this article.

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eneuro: 9 (3)
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May/June 2022
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Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in the Scn1a Haploinsufficiency Mouse Model of Dravet Syndrome
Jessica Hotard Chancey, MacKenzie Allen Howard
eNeuro 6 May 2022, 9 (3) ENEURO.0080-22.2022; DOI: 10.1523/ENEURO.0080-22.2022

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Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in the Scn1a Haploinsufficiency Mouse Model of Dravet Syndrome
Jessica Hotard Chancey, MacKenzie Allen Howard
eNeuro 6 May 2022, 9 (3) ENEURO.0080-22.2022; DOI: 10.1523/ENEURO.0080-22.2022
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Keywords

  • Dravet syndrome
  • epilepsy
  • mouse models
  • Scn1a
  • synaptic integration
  • synaptic transmission

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