Article Figures & Data
Figures
- Figure 1.
The effect of VGLUT3 deletion on glutamate and nonglutamate receptor expression in the mouse cerebral cortex. A–G, Representative immunoblots and quantification of cell surface and total levels of mGluR5 (A), mGluR2/3 (B), NMDAR2A (C), NMDAR2B (D), GluA1 (E), D1R (F), and M1 mAChR (G) in cortical lysates from VGLUT3−/− and C57BL/6 (WT) male mice. Data are the mean ± SEM (n = 5–6 mice/group), normalized to the respective surface or total WT values. *p < 0.05 assessed by unpaired Student’s t test.
- Figure 2.
The effect of VGLUT3 deletion on glutamate and nonglutamate receptors expression in the mouse hippocampus. A–G, Representative immunoblots and quantification of cell surface and total levels of mGluR5 (A), mGluR2/3 (B), NMDAR2A (C), NMDAR2B (D), GluA1 (E), D1R (F), and M1 mAChR (G) in hippocampal lysates from VGLUT3−/− and C57BL/6 (WT) male mice. Data are the mean ± SEM (n = 5–6 mice/group), normalized to the respective surface or total WT values. *p < 0.05 assessed by unpaired Student’s t test.
- Figure 3.
The effect of VGLUT3 deletion on glutamate and nonglutamate receptor expression in the mouse striatum. A–G, Representative immunoblots and quantification of cell surface and total levels of mGluR5 (A), mGluR2/3 (B), NMDAR2A (C), NMDAR2B (D), GluA1 (E), D1R (F), and M1 mAChR (G) in striatal lysates from VGLUT3−/− and C57BL/6 (WT) male mice. Data are the mean ± SEM (n = 5–6 mice/group), normalized to the respective surface or total WT values. *p < 0.05 assessed by unpaired Student’s t test.
Tables
- Table 1
Summary of changes in cell surface and total levels of receptors in the different brain regions of VGLUT3–/– mice
Brain regions mGluR5 mGluR2/3 NMDAR2A NMDAR2B GluA1 D1R M1 mAChR Surface Total Surface Total Surface Total Surface Total Surface Total Surface Total Surface Total Cerebral cortex ↑ ↑ - ↑ - - ↓ - ↑ ↑ ↓ - - - Hippocampus ↓ - - - ↓ - ↓ - - ↑ ↓ - ↓ - Striatum ↑ - - ↑ - - - - ↑ ↑ - - - - (-) denotes no change.
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