Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Sensory and Motor Systems

Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype

Louise Thiry, Chloé Lemaire, Ali Rastqar, Maxime Lemieux, Jimmy Peng, Julien Ferent, Marie Roussel, Eric Beaumont, James P. Fawcett, Robert M. Brownstone, Frédéric Charron and Frédéric Bretzner
eNeuro 3 February 2022, 9 (2) ENEURO.0216-18.2021; https://doi.org/10.1523/ENEURO.0216-18.2021
Louise Thiry
1Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Centre Hospitalier de l’Université Laval (CHUL)–Neurosciences P09800, Quebec City, Quebec G1V 4G2, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chloé Lemaire
1Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Centre Hospitalier de l’Université Laval (CHUL)–Neurosciences P09800, Quebec City, Quebec G1V 4G2, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ali Rastqar
1Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Centre Hospitalier de l’Université Laval (CHUL)–Neurosciences P09800, Quebec City, Quebec G1V 4G2, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maxime Lemieux
1Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Centre Hospitalier de l’Université Laval (CHUL)–Neurosciences P09800, Quebec City, Quebec G1V 4G2, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jimmy Peng
2Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Quebec H2W 1R7, Canada
3Department of Biology, McGill University, Montréal, Quebec H3G 0B1, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julien Ferent
2Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Quebec H2W 1R7, Canada
3Department of Biology, McGill University, Montréal, Quebec H3G 0B1, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marie Roussel
1Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Centre Hospitalier de l’Université Laval (CHUL)–Neurosciences P09800, Quebec City, Quebec G1V 4G2, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eric Beaumont
4Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James P. Fawcett
5Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada
6Department of Surgery, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert M. Brownstone
7University College London (UCL) Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Robert M. Brownstone
Frédéric Charron
2Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Quebec H2W 1R7, Canada
3Department of Biology, McGill University, Montréal, Quebec H3G 0B1, Canada
8Department of Medicine, University of Montreal, Montréal, Quebec H3C 3J7, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Frédéric Charron
Frédéric Bretzner
1Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Centre Hospitalier de l’Université Laval (CHUL)–Neurosciences P09800, Quebec City, Quebec G1V 4G2, Canada
9Department of Psychiatry and Neurosciences, Université Laval, Quebec City, Quebec G1V 4G2, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Frédéric Bretzner
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0216-18.2021
PubMed 
35115383
Published By 
Society for Neuroscience
History 
  • Received May 31, 2018
  • Revision received December 18, 2021
  • Accepted December 20, 2021
  • Published online February 3, 2022.
Copyright & Usage 
Copyright © 2022 Thiry et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Louise Thiry1,*,
  2. Chloé Lemaire1,*,
  3. Ali Rastqar1,*,
  4. Maxime Lemieux1,*,
  5. Jimmy Peng2,3,*,
  6. Julien Ferent2,3,
  7. Marie Roussel1,
  8. Eric Beaumont4,
  9. James P. Fawcett5,6,
  10. Robert M. Brownstone7,
  11. Frédéric Charron2,3,8,† and
  12. Frédéric Bretzner1,9,†
  1. 1Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Centre Hospitalier de l’Université Laval (CHUL)–Neurosciences P09800, Quebec City, Quebec G1V 4G2, Canada
  2. 2Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Quebec H2W 1R7, Canada
  3. 3Department of Biology, McGill University, Montréal, Quebec H3G 0B1, Canada
  4. 4Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604
  5. 5Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada
  6. 6Department of Surgery, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada
  7. 7University College London (UCL) Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
  8. 8Department of Medicine, University of Montreal, Montréal, Quebec H3C 3J7, Canada
  9. 9Department of Psychiatry and Neurosciences, Université Laval, Quebec City, Quebec G1V 4G2, Canada
  1. Correspondence should be addressed to Frédéric Charron at frederic.charron{at}ircm.qc.ca or Frédéric Bretzner at frederic.bretzner.1{at}ulaval.ca.
View Full Text

Author contributions

  1. Author contributions: R.M.B., J.P.F., F.C., and F.B. designed research; L.T., C.L., A.R., M.L., J.P., M.R., J.F., E.B., and F.B. performed research; L.T., C.L., A.R., M.L., J.P., M.R., J.F., E.B., F.C., and F.B. analyzed data; L.T., C.L., M.L., J.P., F.C., and F.B. wrote the paper.

  2. ↵* L.T., C.L., A.R., M.L. and J.P. contributed equally to this work.

  3. ↵† F.C. and F.B. are co-senior authors.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Canadian Institutes of Health Research (CIHR) Grant 334023, the Fonds de Recherche du Québec-Santé (FRQS) Grant 27003, and the Canada Foundation for Innovation (CFI) Grant 33768 (to F.C.); CIHR Grants MOP 341174 (to J.P.F.) and 79413 (to R.M.B.); and the Natural Sciences and Engineering Research Council of Canada (NSERC) Grant 2018-06218 (to F.B.). J.P. was supported by a CIHR Vanier Canada Graduate scholarship. J.F. was supported by FRQS and CIHR fellowships. F.C. holds the Canada Research Chair in Developmental Neurobiology. F.B. is a FRQS Chercheur-Boursier (284011).

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    334023
  • Fonds de Recherche du Québec - Santé (FRQS)

    27003; 284001
  • Canadian Foundation for Innovation

    33768
  • Gouvernement du Canada | CIHR | Institute of Neurosciences, Mental Health and Addiction (INMHA)

    341174; 79413
  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

    2018-06218

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 03, 2022).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-07-12
to
E.g., 2025-07-12

Article usage: February 2022 to July 2025

AbstractFullPdf
Feb 20223880134
Mar 202298227137
Apr 202234186122
May 20221312342
Jun 20221711824
Jul 202286214
Aug 202236721
Sep 202276622
Oct 202247419
Nov 202228115
Dec 202205419
Total 20225741058569
Jan 202326823
Feb 202327621
Mar 202327517
Apr 202308810
May 202307514
Jun 20231737
Jul 202379016
Aug 202327523
Sep 2023410519
Oct 202339916
Nov 202319514
Dec 2023612133
Total 2023301040213
Jan 2024310211
Feb 2024110516
Mar 202429212
Apr 202438518
May 202439016
Jun 2024410522
Jul 202449719
Aug 202469625
Sep 202449215
Oct 202408912
Nov 2024211125
Dec 202439421
Total 2024351158212
Jan 2025310824
Feb 2025210818
Mar 2025111029
Apr 2025511613
May 2025512317
Jun 2025161088
Jul 20251314
Total 202533704113
Total67239601107
Back to top

In this issue

eneuro: 9 (2)
eNeuro
Vol. 9, Issue 2
March/April 2022
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype
Louise Thiry, Chloé Lemaire, Ali Rastqar, Maxime Lemieux, Jimmy Peng, Julien Ferent, Marie Roussel, Eric Beaumont, James P. Fawcett, Robert M. Brownstone, Frédéric Charron, Frédéric Bretzner
eNeuro 3 February 2022, 9 (2) ENEURO.0216-18.2021; DOI: 10.1523/ENEURO.0216-18.2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype
Louise Thiry, Chloé Lemaire, Ali Rastqar, Maxime Lemieux, Jimmy Peng, Julien Ferent, Marie Roussel, Eric Beaumont, James P. Fawcett, Robert M. Brownstone, Frédéric Charron, Frédéric Bretzner
eNeuro 3 February 2022, 9 (2) ENEURO.0216-18.2021; DOI: 10.1523/ENEURO.0216-18.2021
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
    • Author Response
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • CPG
  • DCC
  • locomotion
  • mutant mice

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Novel roles for the GPI-anchor cleaving enzyme, GDE2, in hippocampal synaptic morphology and function
  • Upright posture: a singular condition stabilizing sensorimotor coordination
  • Serotonergic signaling governs C. elegans sensory response to conflicting chemosensory stimuli.
Show more Research Article: New Research

Sensory and Motor Systems

  • Upright posture: a singular condition stabilizing sensorimotor coordination
  • Serotonergic signaling governs C. elegans sensory response to conflicting chemosensory stimuli.
  • Cerebellum involvement in visuo-vestibular interaction for the perception of gravitational direction: a repetitive transcranial magnetic stimulation study
Show more Sensory and Motor Systems

Subjects

  • Sensory and Motor Systems
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.