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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Biophysical Modeling of Dopaminergic Denervation Landscapes in the Striatum Reveals New Therapeutic Strategy

Mathias L. Heltberg, Hussein N. Awada, Alessandra Lucchetti, Mogens H. Jensen, Jakob K. Dreyer and Rune N. Rasmussen
eNeuro 14 February 2022, 9 (2) ENEURO.0458-21.2022; https://doi.org/10.1523/ENEURO.0458-21.2022
Mathias L. Heltberg
1Laboratoire de Physique, École Normale Supérieure, 75231 Paris Cedex 05, France
2Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark
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Hussein N. Awada
3Section of Surgical Pathophysiology, University Hospital Copenhagen, 2200 Copenhagen, Denmark
4Department of Anesthesiology, University Hospital Copenhagen, 2200 Copenhagen, Denmark
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Alessandra Lucchetti
2Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark
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Mogens H. Jensen
2Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark
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Jakob K. Dreyer
5Department of Neuroscience, University of Copenhagen, 2200 Copenhagen, Denmark
6Department of Bioinformatics, H Lundbeck A/S, 2500 Valby, Denmark
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Rune N. Rasmussen
7Center for Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0458-21.2022
PubMed 
35165198
Published By 
Society for Neuroscience
History 
  • Received October 28, 2021
  • Revision received December 22, 2021
  • Accepted January 10, 2022
  • Published online February 14, 2022.
Copyright & Usage 
Copyright © 2022 Heltberg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Mathias L. Heltberg1,2,
  2. Hussein N. Awada3,4,
  3. Alessandra Lucchetti2,
  4. Mogens H. Jensen2,
  5. Jakob K. Dreyer5,6 and
  6. Rune N. Rasmussen7
  1. 1Laboratoire de Physique, École Normale Supérieure, 75231 Paris Cedex 05, France
  2. 2Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark
  3. 3Section of Surgical Pathophysiology, University Hospital Copenhagen, 2200 Copenhagen, Denmark
  4. 4Department of Anesthesiology, University Hospital Copenhagen, 2200 Copenhagen, Denmark
  5. 5Department of Neuroscience, University of Copenhagen, 2200 Copenhagen, Denmark
  6. 6Department of Bioinformatics, H Lundbeck A/S, 2500 Valby, Denmark
  7. 7Center for Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark
  1. Correspondence should be addressed to Rune N. Rasmussen at rune.nguyen.rasmussen{at}sund.ku.dk.
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Author contributions

  1. Author contributions: M.L.H., H.N.A., M.H.J., J.K.D., and R.N.R. designed research; M.L.H. and A.L. performed research; M.L.H., H.N.A., A.L., and R.N.R. analyzed data; M.L.H., H.N.A., M.H.J., J.K.D., and R.N.R. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • R.N.R. was supported by the Lundbeck Foundation Grant R230-2016-2326. M.L.H. and M.H.J. were supported by the Danish Council for Independent Research and StemPhys DNRF Center of Excellence Grant DNRF116. M.L.H. was supported by the Lundbeck Foundation Grant R347-2020-2250).

Funding

  • Lundbeckfonden (Lundbeck Foundation)

    R347-2020-2250; R230-2016-2326
  • Danish Council for Independent Research

  • StemPhys DNRF Center of Excellence

    DNRF116

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 14, 2022).

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Biophysical Modeling of Dopaminergic Denervation Landscapes in the Striatum Reveals New Therapeutic Strategy
Mathias L. Heltberg, Hussein N. Awada, Alessandra Lucchetti, Mogens H. Jensen, Jakob K. Dreyer, Rune N. Rasmussen
eNeuro 14 February 2022, 9 (2) ENEURO.0458-21.2022; DOI: 10.1523/ENEURO.0458-21.2022

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Biophysical Modeling of Dopaminergic Denervation Landscapes in the Striatum Reveals New Therapeutic Strategy
Mathias L. Heltberg, Hussein N. Awada, Alessandra Lucchetti, Mogens H. Jensen, Jakob K. Dreyer, Rune N. Rasmussen
eNeuro 14 February 2022, 9 (2) ENEURO.0458-21.2022; DOI: 10.1523/ENEURO.0458-21.2022
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Keywords

  • biophysics
  • Parkinson’s disease

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