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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Agmatine Alleviates Cisplatin-Induced Ototoxicity by Activating PI3K/AKT Signaling Pathway

Ying Zhang, Zhe Lv and Qiang He
eNeuro 7 March 2022, 9 (2) ENEURO.0434-21.2022; DOI: https://doi.org/10.1523/ENEURO.0434-21.2022
Ying Zhang
Department of Otolaryngology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
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Zhe Lv
Department of Otolaryngology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
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Qiang He
Department of Otolaryngology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0434-21.2022
PubMed 
35256453
Published By 
Society for Neuroscience
History 
  • Received October 13, 2021
  • Revision received February 18, 2022
  • Accepted February 23, 2022
  • Published online March 7, 2022.
Copyright & Usage 
Copyright © 2022 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ying Zhang,
  2. Zhe Lv and
  3. Qiang He
  1. Department of Otolaryngology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
  1. Correspondence should be addressed to Qiang He at qianghe{at}hb2h.com.
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Author contributions

  1. Author contributions: Y.Z. and Q.H. designed research; Y.Z., Z.L., and Q.H. performed research; Y.Z., Z.L., and Q.H. contributed unpublished reagents/analytic tools; Y.Z., Z.L., and Q.H. analyzed data; Y.Z. and Q.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Key Project of Medical Science Research in Hebei Province in 2018 (20180338).

Funding

  • the Key Project of Medical Science Research in Hebei Province in 2018

    20180338

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eneuro: 9 (2)
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Agmatine Alleviates Cisplatin-Induced Ototoxicity by Activating PI3K/AKT Signaling Pathway
Ying Zhang, Zhe Lv, Qiang He
eNeuro 7 March 2022, 9 (2) ENEURO.0434-21.2022; DOI: 10.1523/ENEURO.0434-21.2022

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Agmatine Alleviates Cisplatin-Induced Ototoxicity by Activating PI3K/AKT Signaling Pathway
Ying Zhang, Zhe Lv, Qiang He
eNeuro 7 March 2022, 9 (2) ENEURO.0434-21.2022; DOI: 10.1523/ENEURO.0434-21.2022
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Keywords

  • agmatine
  • cisplatin-induced ototoxicity
  • PI3K/AKT

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