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Research ArticleResearch Article: New Research, Disorders of the Nervous System

The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel NaV1.7 via the Ubiquitin-Ligase NEDD4-2

Alexandru-Florian Deftu, Paul Chu Sin Chung, Cédric J. Laedermann, Ludovic Gillet, Marie Pertin, Guylène Kirschmann and Isabelle Decosterd
eNeuro 7 February 2022, 9 (2) ENEURO.0409-21.2022; https://doi.org/10.1523/ENEURO.0409-21.2022
Alexandru-Florian Deftu
1Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
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Paul Chu Sin Chung
1Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
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Cédric J. Laedermann
1Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
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Ludovic Gillet
1Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
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Marie Pertin
1Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
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Guylène Kirschmann
1Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
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Isabelle Decosterd
1Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
2Department of Fundamental Neurosciences, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0409-21.2022
PubMed 
35131865
Published By 
Society for Neuroscience
History 
  • Received July 20, 2021
  • Revision received December 10, 2021
  • Accepted January 1, 2022
  • Published online February 7, 2022.
Copyright & Usage 
Copyright © 2022 Deftu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alexandru-Florian Deftu1,*,
  2. Paul Chu Sin Chung1,*,
  3. Cédric J. Laedermann1,
  4. Ludovic Gillet1,
  5. Marie Pertin1,
  6. Guylène Kirschmann1 and
  7. Isabelle Decosterd1,2
  1. 1Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
  2. 2Department of Fundamental Neurosciences, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland
  1. Correspondence should be addressed to Isabelle Decosterd at isabelle.decosterd{at}chuv.ch.
View Full Text

Author contributions

  1. Author contributions: C.J.L. and I.D. designed research; C.J.L., L.G., M.P., and G.K. performed research; G.K. contributed unpublished reagents/analytic tools; A.-F.D., P.C.S.C., C.J.L., L.G., and M.P. analyzed data; A.-F.D., P.C.S.C., L.G., and I.D. wrote the paper.

  2. ↵* A.-F.D. and P.C.S.C. contributed equally to this work.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Swiss National Science Foundation (ID #310030_179169). We thank Dr. Marc Suter [Pain Center, Service of Anesthesiology, Lausanne University Hospital (CHUV)] for his constructive feedback on the study. We also thank Dr. Olivier Staub and Dr. Miguel Van Bemmelen (Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne) and Dr. Hughes Abriel (Institute of Biochemistry and Molecular Medicine, University of Bern) for the discussions that permitted the start of this study. C.J.L. currently has a position as Clinical Research Scientist (Medical Advisor) at Eli Lilly (Suisse) SA. L.G currently has a position as Clinical Scientist for Cardiovascular Diseases at Roche Diagnostics. The graphical abstract was adapted from images available on Servier Medical Art (CC-BY 3.0; https://smart.servier.com/).

Funding

  • Swiss National Science Foundation

    ID; # 310030_179169

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  • You are viewing the most recent version of this article.
  • previous version (February 07, 2022).

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Total106251031897
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The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel NaV1.7 via the Ubiquitin-Ligase NEDD4-2
Alexandru-Florian Deftu, Paul Chu Sin Chung, Cédric J. Laedermann, Ludovic Gillet, Marie Pertin, Guylène Kirschmann, Isabelle Decosterd
eNeuro 7 February 2022, 9 (2) ENEURO.0409-21.2022; DOI: 10.1523/ENEURO.0409-21.2022

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The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel NaV1.7 via the Ubiquitin-Ligase NEDD4-2
Alexandru-Florian Deftu, Paul Chu Sin Chung, Cédric J. Laedermann, Ludovic Gillet, Marie Pertin, Guylène Kirschmann, Isabelle Decosterd
eNeuro 7 February 2022, 9 (2) ENEURO.0409-21.2022; DOI: 10.1523/ENEURO.0409-21.2022
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Keywords

  • dorsal root ganglion
  • metformin
  • NaV1.7
  • NEDD4-2
  • pain

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