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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Transient Response of Basal Ganglia Network in Healthy and Low-Dopamine State

Kingshuk Chakravarty, Sangheeta Roy, Aniruddha Sinha, Atsushi Nambu, Satomi Chiken, Jeanette Hellgren Kotaleski and Arvind Kumar
eNeuro 9 February 2022, 9 (2) ENEURO.0376-21.2022; https://doi.org/10.1523/ENEURO.0376-21.2022
Kingshuk Chakravarty
1TCS Research, Tata Consultancy Services, Kolkata, 700160, India
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Sangheeta Roy
1TCS Research, Tata Consultancy Services, Kolkata, 700160, India
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Aniruddha Sinha
1TCS Research, Tata Consultancy Services, Kolkata, 700160, India
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  • ORCID record for Aniruddha Sinha
Atsushi Nambu
2Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan
3Department of Physiological Sciences, SOKENDAI (Graduate University for Advanced Studies), Okazaki, 444-8585, Japan
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Satomi Chiken
2Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan
3Department of Physiological Sciences, SOKENDAI (Graduate University for Advanced Studies), Okazaki, 444-8585, Japan
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Jeanette Hellgren Kotaleski
4Department of Computational Science and Technology, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, SE-10044, Sweden
5Department of Neuroscience, Karolinska Institute, Stockholm, SE 171 77, Sweden
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Arvind Kumar
4Department of Computational Science and Technology, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, SE-10044, Sweden
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0376-21.2022
PubMed 
35140075
Published By 
Society for Neuroscience
History 
  • Received September 15, 2021
  • Revision received December 27, 2021
  • Accepted January 4, 2022
  • Published online February 9, 2022.
Copyright & Usage 
Copyright © 2022 Chakravarty et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kingshuk Chakravarty1,
  2. Sangheeta Roy1,
  3. Aniruddha Sinha1,
  4. Atsushi Nambu2,3,
  5. Satomi Chiken2,3,
  6. Jeanette Hellgren Kotaleski4,5 and
  7. Arvind Kumar4
  1. 1TCS Research, Tata Consultancy Services, Kolkata, 700160, India
  2. 2Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan
  3. 3Department of Physiological Sciences, SOKENDAI (Graduate University for Advanced Studies), Okazaki, 444-8585, Japan
  4. 4Department of Computational Science and Technology, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, SE-10044, Sweden
  5. 5Department of Neuroscience, Karolinska Institute, Stockholm, SE 171 77, Sweden
  1. Correspondence should be addressed to Arvind Kumar at arvkumar{at}kth.se or Kingshuk Chakravarty at kingshuk.chakravarty{at}tcs.com.
View Full Text

Author contributions

  1. Author contributions: A.N. and A.K. designed research; K.C., S.R., and A.S. performed research; K.C., S.R., A.S., A.N., S.C., J.H.K., and A.K. contributed unpublished reagents/analytic tools; K.C., S.R., A.S., and A.K. analyzed data; K.C., S.R., A.S., A.N., S.C., J.H.K., and A.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • A.K. was supported by the Swedish Research Council Grant VR-M-2018-03118, StratNEURO, KTH Digital Futures Project dBRAIN, and STINT (Joint Japan-Sweden Research Collaboration). J.H.K. was supported by the Swedish Research Council Grant VR-M-2017-02806, KTH Digital Futures Project dBRAIN, the Swedish e-Science Research Center, the European Union Seventh Framework Programme Grant FP7/2007-2013, EU/Horizon 2020 Grants 720270 HBP SGA1 and Grant 785907 HBP SGA2, and the European Union/Horizon 2020 Grant 945539 (Human Brain Project, SGA3). K.C., A.S., and S.R. were supported by the TCS Research division of the Tata Consultancy Services. A.N. was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI (“Non-linear Neurooscillology,” Grant 15H05873), the Japan Society for the promotion of Science KAKENHI Grant 19KK0193, Japan Agency for Medical Research and Development Grants JP18dm0307005 and JP21dm0207015, and JSPS-STINT (Joint Japan Sweden Research Grant).

Funding

  • Vetenskapsrådet (VR)

    VR-M-2018-03118; VR-M-2017-02806; StratNEUro; SeRC BrainIT
  • Digital Futures

    dBrain
  • EU

    FP7/2007-2013; 720270 HBP SGA1; 785907 HBP SGA2
  • TCS Research division

  • JSPS KAKENHI

    19KK0193
  • MEXT KAKENHI

    15H05873
  • STINT Sweden

  • Japan Agency for Medical Research and Development (AMED)

    JP21dm0307005 and JP21dm0207015

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 09, 2022).

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Transient Response of Basal Ganglia Network in Healthy and Low-Dopamine State
Kingshuk Chakravarty, Sangheeta Roy, Aniruddha Sinha, Atsushi Nambu, Satomi Chiken, Jeanette Hellgren Kotaleski, Arvind Kumar
eNeuro 9 February 2022, 9 (2) ENEURO.0376-21.2022; DOI: 10.1523/ENEURO.0376-21.2022

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Transient Response of Basal Ganglia Network in Healthy and Low-Dopamine State
Kingshuk Chakravarty, Sangheeta Roy, Aniruddha Sinha, Atsushi Nambu, Satomi Chiken, Jeanette Hellgren Kotaleski, Arvind Kumar
eNeuro 9 February 2022, 9 (2) ENEURO.0376-21.2022; DOI: 10.1523/ENEURO.0376-21.2022
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Keywords

  • basal ganglia
  • direct pathway
  • indirect pathway
  • Network model
  • Parkinson’s disease
  • Transient response

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